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SMURF1 [cytosol]
Stable Identifier
R-CFA-975972
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SMURF1, F1PQT6
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
ub-PTCH1:SMURF [ciliary membrane] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by BMP (Canis familiaris)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Canis familiaris)
I-SMAD:SMURF [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
I-SMAD:SMURF [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Canis familiaris)
Disassembly of tight junctions (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
SMURF1 binds phosphorylated PARD6A (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
SMURF1 ubiquitinates RHOA (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
Asymmetric localization of PCP proteins (Canis familiaris)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Canis familiaris)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1PQT6
Gene Names
SMURF1
Reference Genes
ENSEMBL:ENSCAFG00000015133
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000015133 SMURF1
Other Identifiers
608821
CfaAffx.23308.1.S1_at
GO:0000209
GO:0000902
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005886
GO:0006464
GO:0006511
GO:0006605
GO:0006611
GO:0006810
GO:0006913
GO:0006914
GO:0007034
GO:0007165
GO:0008150
GO:0009056
GO:0015031
GO:0016567
GO:0022607
GO:0030154
GO:0030509
GO:0030512
GO:0030514
GO:0030579
GO:0032801
GO:0034394
GO:0040007
GO:0043161
GO:0043226
GO:0048856
GO:0061024
GO:0061630
GO:0061736
GO:0061753
GO:0070411
GO:0070412
GO:0071211
GO:1903861
GO:2000060
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
as an input of
SMURF1 binds phosphorylated PARD6A (Canis familiaris)
as a component of
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
as a member of
SMURF [cytosol] (Canis familiaris)
Other forms of this molecule
SMURF1 [nucleoplasm]
Inferred From
SMURF1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000198742
Ensembl
ENSCAFG00000015133
,
ENSCAFP00000022329
,
ENSCAFT00000024051
VGNC
46580
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