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What is Reactome ?
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FBXW11 [cytosol]
Stable Identifier
R-CFA-976035
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A5F4BPT4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXW11 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A5F4BPT4
Reference Genes
ENSEMBL:ENSCAFG00000016890
Participates
as a member of
F-box protein [cytosol] (Canis familiaris)
as a component of
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Inferred From
beta-TrCP [cytosol]
(Homo sapiens)
FBXW11 [cytosol]
(Homo sapiens)
Cross References
VGNC
40792
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