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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Analysis Gene Expression
Species Comparison
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Diseases
Cytomics
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TNF [extracellular region]
Stable Identifier
R-CFA-976821
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
TNF(77-233), P51742
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:DENN-SV,MADD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Canis familiaris)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha inhibitors bind to soluble TNF trimer (Canis familiaris)
TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNFR1-mediated ceramide production (Canis familiaris)
TNF-α:TNFR1 binds NSMAF (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:NSMAF [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)
TNF-α:TNFR1:NSMAF [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:NSMAF [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)
TNF-alpha:TNFR1:NSMAF:GNB2L1:SMPD2,3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:NSMAF [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:NSMAF [plasma membrane] (Canis familiaris)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Canis familiaris)
soluble TNF-α:TNFR1 [plasma membrane] (Canis familiaris)
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
TNF [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:P51742
Gene Names
TNF
Reference Genes
BioGPS Gene:403922 TNF
ENSEMBL:ENSCAFG00030005072
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000000517.5 TNF
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030005072.1 TNF
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040009744.1 TNF
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805014361 TNF
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845010558.1 TNF
KEGG Gene (Canis lupus familiaris):403922 TNF
Monarch:403922 TNF
NCBI Gene:403922 TNF
Reference Transcript
RefSeq:NM_001003244.4 TNF
Other Identifiers
403922
Cfa.54.1.S1_s_at
CfaAffx.1718.1.S1_at
GO:0000122
GO:0000278
GO:0000976
GO:0001774
GO:0001819
GO:0001891
GO:0001932
GO:0001934
GO:0001937
GO:0002020
GO:0002281
GO:0002376
GO:0002439
GO:0002637
GO:0002719
GO:0002876
GO:0002925
GO:0003677
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005886
GO:0005975
GO:0006006
GO:0006351
GO:0006355
GO:0006629
GO:0006766
GO:0006952
GO:0006954
GO:0006955
GO:0006959
GO:0007010
GO:0007155
GO:0007249
GO:0007254
GO:0008625
GO:0008630
GO:0009615
GO:0009887
GO:0009897
GO:0009986
GO:0010033
GO:0010573
GO:0010628
GO:0010629
GO:0012501
GO:0016020
GO:0023052
GO:0030154
GO:0030163
GO:0030198
GO:0030316
GO:0030730
GO:0030866
GO:0031334
GO:0031410
GO:0031622
GO:0032715
GO:0032722
GO:0032729
GO:0032731
GO:0032755
GO:0032757
GO:0033138
GO:0033209
GO:0034116
GO:0034330
GO:0036211
GO:0038177
GO:0042060
GO:0042127
GO:0042742
GO:0042802
GO:0043065
GO:0043068
GO:0043122
GO:0043123
GO:0043226
GO:0043242
GO:0043243
GO:0043410
GO:0043491
GO:0043525
GO:0043537
GO:0045071
GO:0045121
GO:0045123
GO:0045429
GO:0045662
GO:0045668
GO:0045670
GO:0045672
GO:0045732
GO:0045785
GO:0045892
GO:0045893
GO:0045930
GO:0045944
GO:0045994
GO:0046325
GO:0046330
GO:0048018
GO:0048566
GO:0048661
GO:0048856
GO:0048870
GO:0050708
GO:0050727
GO:0050796
GO:0050806
GO:0050807
GO:0050830
GO:0050900
GO:0050901
GO:0050995
GO:0051044
GO:0051173
GO:0051222
GO:0051384
GO:0051798
GO:0051897
GO:0055037
GO:0055085
GO:0060252
GO:0060557
GO:0060664
GO:0060693
GO:0061044
GO:0061048
GO:0065003
GO:0070886
GO:0071222
GO:0071230
GO:0071316
GO:0071346
GO:0071803
GO:0072577
GO:0072659
GO:0090594
GO:0097190
GO:0097191
GO:0097527
GO:0098542
GO:0098772
GO:0140374
GO:0150129
GO:1900017
GO:1900222
GO:1901224
GO:1901647
GO:1902004
GO:1902895
GO:1903078
GO:1903140
GO:1903347
GO:1903721
GO:1904707
GO:1904996
GO:1904999
GO:2000010
GO:2000334
GO:2000343
GO:2000351
GO:2000377
GO:2001234
GO:2001240
Participates
as a component of
TNF-α trimer, soluble form [extracellular region] (Canis familiaris)
Other forms of this molecule
TNF [extracellular region]
TNF [plasma membrane]
TNF [plasma membrane]
TNF [plasma membrane]
Inferred From
TNF(77-233) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001003244.4
OpenTargets
ENSG00000232810
Ensembl
ENSCAFT00845018595
,
ENSCAFP00845014504
,
ENSCAFG00845010558
VGNC
47647
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