Reactome | PRLR [plasma membrane]

PRLR [plasma membrane]

Stable Identifier

R-CFA-976964

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

PRLR, A0A8I3MFS4

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Growth hormone receptor signaling (Canis familiaris)
    - JAK2 phosphorylation (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
  - Prolactin receptor signaling (Canis familiaris)
    - JAK2 phosphorylation (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Canis familiaris)
        
        Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
    - PRLR activation (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
    - PRLR is phosphorylated at Ser-349 (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
    - PRLR:JAK2 dimerizes (Canis familiaris)
      - PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
    - Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
    - SH2B binds JAK2 (Canis familiaris)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Canis familiaris)
        
        PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 dimer [plasma membrane] (Canis familiaris)
        
        PRLR:JAK2 [plasma membrane] (Canis familiaris)
        
        PRLR [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MFS4

Gene Names

PRLR

Reference Genes

BioGPS Gene:479363 PRLR

ENSEMBL:ENSCAFG00845000774.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000774.1 PRLR

KEGG Gene (Canis lupus familiaris):479363 PRLR

Monarch:479363 PRLR

NCBI Gene:479363 PRLR

Reference Transcript

Other Identifiers

479363

CfaAffx.28688.1.S1_at

GO:0004925

GO:0005515

GO:0007155

GO:0007259

GO:0007595

GO:0008289

GO:0009617

GO:0009986

GO:0012501

GO:0016020

GO:0017046

GO:0022414

GO:0023052

GO:0030154

GO:0030155

GO:0030856

GO:0038161

GO:0043066

GO:0046872

GO:0048856

GO:0060089

GO:0060644

GO:0060736

GO:0060749

GO:0061180

GO:0120162

Participates

as a component of

Other forms of this molecule

phospho-PRLR [endosome lumen]

phospho-PRLR [plasma membrane]

Inferred From

PRLR [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005619456.1, XP_013968623.1

OpenTargets

ENSG00000113494

Ensembl

ENSCAFP00845001007, ENSCAFT00845001307, ENSCAFG00845000774