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PLCG2 [cytosol]
Stable Identifier
R-CFA-984806
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PLCG2, A0A8I3NZG2
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
Dectin-2 family (Canis familiaris)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation of BTK by p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-SYK/p-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation and activation of VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Recruitment of VAV to p-SLP-76 (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
Phosphorylation and activation of PLCG (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Recruitment of PLCgamma to membrane (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
PLC gamma1,2 [cytosol] (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
Endocytosis of TLR4:LY96:LPS:CD14 (Canis familiaris)
PLCG2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NZG2
Gene Names
PLCG2
Reference Genes
ENSEMBL:ENSCAFG00845017949.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845017949.1 PLCG2
Other Identifiers
489692
Cfa.20736.1.S1_s_at
CfaAffx.30601.1.S1_s_at
GO:0001775
GO:0001784
GO:0001878
GO:0002092
GO:0002223
GO:0002224
GO:0002281
GO:0002316
GO:0002376
GO:0002732
GO:0003824
GO:0004435
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0006661
GO:0006954
GO:0007165
GO:0008081
GO:0009395
GO:0010468
GO:0010628
GO:0012501
GO:0016042
GO:0016192
GO:0016787
GO:0019216
GO:0019722
GO:0019901
GO:0023052
GO:0030154
GO:0030183
GO:0031663
GO:0032481
GO:0032496
GO:0032587
GO:0032733
GO:0032735
GO:0032743
GO:0032747
GO:0032755
GO:0032760
GO:0032959
GO:0035556
GO:0036211
GO:0043069
GO:0043122
GO:0043226
GO:0043410
GO:0045121
GO:0048471
GO:0048678
GO:0048856
GO:0050731
GO:0050850
GO:0050852
GO:0050853
GO:0050896
GO:0051209
GO:0055065
GO:0055085
GO:0060100
GO:0060907
GO:0061024
GO:0061760
GO:0065003
GO:0070884
GO:0071277
GO:0071396
GO:0097110
GO:0097708
GO:0098542
GO:0140031
GO:0150078
GO:1900227
GO:1903428
GO:1903721
GO:1990782
GO:1990858
Participates
as a component of
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Canis familiaris)
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Canis familiaris)
PLCG2:PIP3 [plasma membrane] (Canis familiaris)
as an input of
p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
as a member of
PLC gamma1,2 [cytosol] (Canis familiaris)
This entity regulates
Positively
Endocytosis of TLR4:LY96:LPS:CD14
(Canis familiaris)
Other forms of this molecule
phospho-PLCG2 [cytosol]
phospho-PLCG2 [plasma membrane]
phospho-PLCG2 [plasma membrane]
phospho-PLCG2 [plasma membrane]
PLCG2 [plasma membrane]
phospho-PLCG2 [plasma membrane]
Inferred From
PLCG2 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000197943
Ensembl
ENSCAFG00845017949
,
ENSCAFT00845032081
,
ENSCAFP00845025085
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