Reactome | pp1a-nsp10 [cytosol]

pp1a-nsp10 [cytosol]

Stable Identifier

R-COV-9678272

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

cytosol

Synonyms

nsp10, Non-structural protein 10, 1a (4231–4369)

Locations in the PathwayBrowser for interactor UniProt:P0C6U8 1a

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - SARS-CoV Infections (Homo sapiens)
    - SARS-CoV-1 Infection (Homo sapiens)
      - Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
        
        Maturation of replicase proteins (Homo sapiens)
        
        3CLp cleaves nsp6-11 (Homo sapiens)
        
        pp1a-nsp10 [cytosol] (Human SARS coronavirus)

External Reference Information

External Reference

UniProt:P0C6U8 1a

Gene Names

Chain

chain:1-4382, chain:1-180, chain:181-818, chain:819-2740, chain:2741-3240, chain:3241-3546, chain:3547-3836, chain:3837-3919, chain:3920-4117, chain:4118-4230, chain:4231-4369, chain:4370-4382

Participates

as an output of

3CLp cleaves nsp6-11 (Homo sapiens)

as a member of

nsp10 [cytosol] (Human SARS coronavirus)

Other forms of this molecule

pp1a-nsp11 [cytosol]

pp1a-nsp9 [cytosol]

pp1a-nsp6 [endoplasmic reticulum membrane]

N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]

N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]

pp1a-nsp4 [cytosol]

pp1a-nsp3 [cytosol]

N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]

pp1a-nsp6-11 [cytosol]

pp1a-nsp5 [cytosol]

pp1a-nsp2 [cytosol]

pp1a-nsp3-4 [cytosol]

pp1a-nsp1 [cytosol]

pp1a-nsp1-4 [cytosol]

pp1a-nsp6 [double membrane vesicle viral factory outer membrane]

pp1a-nsp4 [double membrane vesicle viral factory outer membrane]

pp1a-nsp3 [double membrane vesicle viral factory outer membrane]

pp1a-nsp7 [cytosol]

pp1a-nsp8 [cytosol]

pp1a [cytosol]

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

ZINC - Investigational

R1A_CVHSA

ZINC - Metabolites

R1A_CVHSA

ZINC - World Drugs

R1A_CVHSA

IntEnz

3.4.22.69

ZINC - Substances

R1A_CVHSA

ZINC target

P0C6U8

ZINC - Biogenic

R1A_CVHSA

ZINC - Predictions - Purchasable

R1A_CVHSA

PDB

2G9T, 3EA7, 7LMI, 2GZ7, 2GZ9, 2FAV, 2DUC, 2D2D, 4OVZ, 3R24, 1Z1I, 7EO8, 1UK2, 2FE8, 3SND, 2GT7, 2GX4, 3VB7, 1WOF, 2LIZ, 2C3S, 3SN8, 2IDY, 6XHN, 1YSY, 2Z3D, 2GT8, 3MJ5, 7LMG, 3SNB, 2ZU4, 3TIT, 2KQV, 5Y3Q, 3M3V, 3M3S, 2KYS, 3EA9, 6NUR, 3F9E, 1UK3, 1QZ8, 4MM3, 1UW7, 3AW0, 2BX4, 2ACF, 2AMQ, 2A5A, 6YXJ, 7K0H, 3TNT, 3FZD, 3VB5, 3VB3, 6LO0, 2ALV, 4M0W, 3E91, 5Y3E, 2HOB, 7LMH, 5F22, 2WCT, 2GZ8, 6Y7M, 3SNC, 2H2Z, 2GRI, 7LMJ, 1UK4, 2PWX, 2W2G, 2A5I, 3SNE, 3SZN, 4OW0, 7K0G, 3F9G, 3V3M, 6W2A, 6XHO, 2Z3C, 2Z3E, 3EA8, 2GTB, 6XHL, 2AHM, 7DQZ, 1UJ1, 7RC1, 3SNA, 2KAF, 3M3T, 3EE7, 6NUS, 2AMD, 2HSX, 3ATW, 2GA6, 1Z1J, 3AVZ, 2GDT, 3AW1, 2OP9, 3EAJ, 3IWM, 2BX3, 2FYG, 2KQW, 3TIU, 2ZU5, 4HI3, 3TNS, 3VB6, 6LNY, 2A5K, 1Q2W, 3F9H, 3F9F, 3VB4, 4MDS

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0C6U8 1a	20	pp1a-nsp11 [cytosol] (R-COV-9678271) pp1a-nsp9 [cytosol] (R-COV-9678273) pp1a-nsp6 [endoplasmic reticulum membrane] (R-COV-9678265) N-glycan pp1a-nsp4 [endoplasmic reticulum membrane] (R-COV-9684271) N-glycan pp1a-nsp3 [endoplasmic reticulum membrane] (R-COV-9678246) pp1a-nsp4 [cytosol] (R-COV-9684342) pp1a-nsp3 [cytosol] (R-COV-9684257) N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane] (R-COV-9684267) pp1a-nsp6-11 [cytosol] (R-COV-9684354) pp1a-nsp5 [cytosol] (R-COV-9678259) pp1a-nsp2 [cytosol] (R-COV-9678250) pp1a-nsp3-4 [cytosol] (R-COV-9684263) pp1a-nsp1 [cytosol] (R-COV-9678243) pp1a-nsp1-4 [cytosol] (R-COV-9684311) pp1a-nsp6 [double membrane vesicle viral factory outer membrane] (R-COV-9686007) pp1a-nsp4 [double membrane vesicle viral factory outer membrane] (R-COV-9685995) pp1a-nsp3 [double membrane vesicle viral factory outer membrane] (R-COV-9686004) pp1a-nsp7 [cytosol] (R-COV-9678266) pp1a-nsp10 [cytosol] (R-COV-9678272) pp1a-nsp8 [cytosol] (R-COV-9678275)	0.558	6

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