Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
nascent Spike [endoplasmic reticulum lumen]
Stable Identifier
R-COV-9682868
Type
Protein [EntityWithAccessionedSequence]
Species
Human SARS coronavirus
Compartment
endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Spike protein gets N-glycosylated (Homo sapiens)
nascent Spike [endoplasmic reticulum lumen] (Human SARS coronavirus)
mRNA2 is translated to Spike (Homo sapiens)
nascent Spike [endoplasmic reticulum lumen] (Human SARS coronavirus)
External Reference Information
External Reference
UniProt:P59594 S
Gene Names
S, 2
Chain
signal peptide:1-13, chain:14-1255, chain:14-667, chain:668-1255, chain:798-1255
Participates
as an output of
mRNA2 is translated to Spike (Homo sapiens)
as an input of
Spike protein gets N-glycosylated (Homo sapiens)
Other forms of this molecule
N-glycan Spike [endoplasmic reticulum lumen]
trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen]
trimmed N-glycan Spike [endoplasmic reticulum lumen]
trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen]
trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
complex N-glycan-PALM-Spike [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYF1 ACE2
5
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
0.988
56
UniProt:P59594 S
12
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9682868)
N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683594)
trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683716)
trimmed N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683608)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen]
(R-COV-9683638)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683657)
complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683617)
complex N-glycan-PALM-Spike [virion membrane]
(R-COV-9685469)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9686730)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9686693)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9686706)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9686724)
0.933
22
UniProt:Q56NL1 ACE2
0.667
4
UniProt:P59635 7a
4
7a [plasma membrane]
(R-COV-9735855)
7a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9686193)
7a [endocytic vesicle membrane]
(R-COV-9686695)
7a [virion membrane]
(R-COV-9678204)
0.646
3
UniProt:O00303 EIF3F
1
EIF3F [cytosol]
(R-HSA-72540)
0.645
5
UniProt:P07711 CTSL
8
CTSL(292-333) [endocytic vesicle lumen]
(R-HSA-9686680)
CTSL(114-288) [endocytic vesicle lumen]
(R-HSA-9686686)
CTSL(114-288) [endolysosome lumen]
(R-HSA-1679050)
CTSL(292-333) [endolysosome lumen]
(R-HSA-1679026)
CTSL1(114-288) [early endosome lumen]
(R-HSA-4127474)
CTSL1(114-288) [lysosomal lumen]
(R-HSA-1181225)
CTSL(292-333) [extracellular region]
(R-HSA-449863)
CTSL(114-288) [extracellular region]
(R-HSA-449861)
0.623
2
UniProt:Q5EGZ1
1
ACE2(18-805) [plasma membrane]
(R-RNO-2022344)
0.524
2
UniProt:P59637 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9683652)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9683767)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9683626)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9683597)
nascent E [endoplasmic reticulum lumen]
(R-COV-9683684)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9683694)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698721)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698722)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698716)
0.491
2
UniProt:P59596 M
10
M [plasma membrane]
(R-COV-9731038)
M [Golgi membrane]
(R-COV-9683651)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9683588)
nascent M [endoplasmic reticulum lumen]
(R-COV-9683586)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9684206)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9684213)
M [endocytic vesicle membrane]
(R-COV-9686687)
N-glycan M [endocytic vesicle membrane]
(R-COV-9686698)
M [virion membrane]
(R-COV-9678151)
N-glycan M [virion membrane]
(R-COV-9685474)
0.463
2
UniProt:P84198 VIME
0.463
2
UniProt:Q1LZX8 Q1LZX8
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text