Reactome | N [cytosol]

N [cytosol]

Stable Identifier

R-COV-9683625

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
12775768	Mass spectrometric characterization of proteins from the SARS virus: a preliminary report Krokhin, O, Li, Y, Andonov, A, Feldmann, H, Flick, R, Jones, S, Stroeher, U, Bastien, N, Dasuri, KV, Cheng, K, Simonsen, JN, Perreault, H, Wilkins, J, Ens, W, Plummer, F, Standing, KG	Mol. Cell Proteomics	2003
15496142	Identification and characterization of the human ARD1-NATH protein acetyltransferase complex Arnesen, T, Anderson, D, Baldersheim, C, Lanotte, M, Varhaug, JE, Lillehaug, JR	Biochem J	2005

External Reference Information

External Reference

UniProt:P59595 N

Gene Names

N, 9a

Chain

chain:1-422

Reference Genes

UCSC:P59595 N

Participates

as a component of

N:TRIM25 [cytosol] (Homo sapiens)

as an input of

as an output of

mRNA9 is translated to Nucleoprotein (Homo sapiens)

This entity regulates

Positively

Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)

Other forms of this molecule

p-S177-N [cytosol]

ADPr-p-S177-N [cytosol]

SUMO1-K62-ADPr-p-S177-N [cytosol]

SUMO1-K62-ADPr-p-S177-N [viral capsid]

SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]

N [plasma membrane]

SUMO1-K62-ADPr-p-S177-N [nucleolus]

SUMO1-K62-ADPr-p-S177-N [plasma membrane]

Inferred To

N [cytosol] (Severe acute respiratory syndrome coronavirus 2)

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

Mondo

0005091

PDB

2GIB, 3I6L, 2OFZ, 1X7Q, 7LG0, 6IEX, 2CJR, 1SSK, 2OG3, 2JW8

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.979	43
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.924	12
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.907	19
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.75	12
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.737	5
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.691	10
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [cytosol] (R-HSA-173123) PPIA [extracellular region] (R-HSA-173646)	0.676	4
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.602	3
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.576	3
UniProt:P59637 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9683652) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9683767) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683626) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683597) nascent E [endoplasmic reticulum lumen] (R-COV-9683684) Ub-3xPalmC-E [Golgi membrane] (R-COV-9683694) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698721) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698722) Ub-3xPalmC-E [virion membrane] (R-COV-9698716)	0.573	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.557	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.544	2
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.537	6
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:Q9BQ75 CMS1			0.527	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.527	2
UniProt:O75683 SURF6			0.527	2
UniProt:Q8NCA5 FA98A			0.527	2
UniProt:Q13310 PABP4			0.527	2
UniProt:P16989 YBOX3			0.527	2
UniProt:P84025	9	Ub-SMAD3 [cytosol] (R-RNO-6782830) phospho-p-S208-SMAD3 [cytosol] (R-RNO-9731114) SMAD3 [nucleoplasm] (R-RNO-206150) phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-RNO-2187326) phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-RNO-9773841) phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (R-RNO-2176471) SMAD3 [cytosol] (R-RNO-170855) phospho-p-S423,S425-SMAD3 [cytosol] (R-RNO-171184) phospho-p-S423,S425-SMAD3 [nucleoplasm] (R-RNO-177104)	0.524	4
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.524	2
IntAct:EBI-5590670 PGH2			0.524	5
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.463	2

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