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SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
Stable Identifier
R-COV-9683641
Type
Protein [EntityWithAccessionedSequence]
Species
Human SARS coronavirus
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
Virion Assembly and Release (Homo sapiens)
Accessory proteins are recruited to the maturing virion (Homo sapiens)
S3:M:E:encapsidated SARS coronavirus genomic RNA:7a:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
S3:M:E:encapsidated SARS coronavirus genomic RNA:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
E and N are recruited to the M lattice (Homo sapiens)
M lattice:E protein:encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)
SUMO-p-N dimer:SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
Recruitment of Spike trimer to assembling virion (Homo sapiens)
M lattice:E protein:encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
S3:M:E:encapsidated SARS coronavirus genomic RNA:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SARS virus buds into ERGIC lumen (Homo sapiens)
S3:M:E:encapsidated SARS coronavirus genomic RNA:7a:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)
SUMO-p-N dimer:SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
Literature References
PubMed ID
Title
Journal
Year
15848177
Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus
Liu, DX
,
Xiao, H
,
Li, FQ
,
Tam, JP
FEBS Lett.
2005
External Reference Information
External Reference
UniProt:P59595 N
Gene Names
N, 9a
Chain
chain:1-422
Participates
as a component of
SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)
Other forms of this molecule
N [cytosol]
p-S177-N [cytosol]
ADPr-p-S177-N [cytosol]
SUMO1-K62-ADPr-p-S177-N [cytosol]
SUMO1-K62-ADPr-p-S177-N [viral capsid]
N [plasma membrane]
SUMO1-K62-ADPr-p-S177-N [nucleolus]
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
Inferred To
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Severe acute respiratory syndrome coronavirus 2)
Modified Residues
Name
O-phospho-L-serine at 177
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
sumoylated lysine (monoSUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]) at 62
Coordinate
62
Modification
monoSUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position
PsiMod Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue
PsiMod Definition
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Cross References
PDB
2CJR
,
6IEX
,
1X7Q
,
2OFZ
,
3I6L
,
1SSK
,
2GIB
,
2JW8
,
2OG3
,
7LG0
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.979
43
UniProt:Q13283 G3BP1
1
G3BP1 [cytosol]
(R-HSA-9729517)
0.924
12
UniProt:P59596 M
10
M [plasma membrane]
(R-COV-9731038)
M [Golgi membrane]
(R-COV-9683651)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9683588)
nascent M [endoplasmic reticulum lumen]
(R-COV-9683586)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9684206)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9684213)
M [endocytic vesicle membrane]
(R-COV-9686687)
N-glycan M [endocytic vesicle membrane]
(R-COV-9686698)
M [virion membrane]
(R-COV-9678151)
N-glycan M [virion membrane]
(R-COV-9685474)
0.907
19
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.75
12
UniProt:Q9UN86 G3BP2
1
G3BP2 [cytosol]
(R-HSA-9729507)
0.737
5
UniProt:Q05639 EEF1A2
1
EEF1A2 [cytosol]
(R-HSA-3907261)
0.691
10
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
0.676
4
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.602
3
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.576
3
UniProt:P59637 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9683652)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9683767)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9683626)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9683597)
nascent E [endoplasmic reticulum lumen]
(R-COV-9683684)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9683694)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698721)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698722)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698716)
0.573
4
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.557
3
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.544
2
UniProt:O75569 PRKRA
2
p-S246,S287-PRKRA [cytosol]
(R-HSA-9834791)
PRKRA [cytosol]
(R-HSA-2399897)
0.537
6
UniProt:P16989 YBOX3
0.527
2
UniProt:Q13310 PABP4
0.527
2
UniProt:Q8NCA5 FA98A
0.527
2
UniProt:O75683 SURF6
0.527
2
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.527
2
UniProt:Q9BQ75 CMS1
0.527
2
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
2
UniProt:Q6PKG0 LARP1
1
LARP1 [cytosol]
(R-HSA-9760421)
0.527
2
IntAct:EBI-5590670 PGH2
0.524
5
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:P61769 B2M
11
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.524
2
UniProt:Q14258 TRIM25
2
TRIM25 [nucleoplasm]
(R-HSA-5653667)
TRIM25 [cytosol]
(R-HSA-918186)
0.463
2
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