Reactome | SUMO1-K62-ADPr-p-S177-N [nucleolus]

SUMO1-K62-ADPr-p-S177-N [nucleolus]

Stable Identifier

R-COV-9683730

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

nucleolus

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15848177	Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus Liu, DX, Xiao, H, Li, FQ, Tam, JP	FEBS Lett.	2005

External Reference Information

External Reference

UniProt:P59595 N

Gene Names

N, 9a

Chain

chain:1-422

Reference Genes

UCSC:P59595 N

Participates

as a component of

SUMO-p-N dimer [nucleolus] (Human SARS coronavirus)

Other forms of this molecule

N [cytosol]

p-S177-N [cytosol]

ADPr-p-S177-N [cytosol]

SUMO1-K62-ADPr-p-S177-N [cytosol]

SUMO1-K62-ADPr-p-S177-N [viral capsid]

SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]

N [plasma membrane]

SUMO1-K62-ADPr-p-S177-N [plasma membrane]

Inferred To

SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (Severe acute respiratory syndrome coronavirus 2)

Modified Residues

Name

O-phospho-L-serine at 177

Coordinate

177

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position

PsiMod Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue

PsiMod Definition

A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.

Name

sumoylated lysine (monoSUMO1 [nucleolus]) at 62

Coordinate

Modification

monoSUMO1 [nucleolus]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

PDB

2OFZ, 1X7Q, 6IEX, 7LG0, 3I6L, 2GIB, 2OG3, 2JW8, 1SSK, 2CJR

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.979	43
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.924	12
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.907	19
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.75	12
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.737	5
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.691	10
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [extracellular region] (R-HSA-173646) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [cytosol] (R-HSA-173123)	0.676	4
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.602	3
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.576	3
UniProt:P59637 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9683652) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9683767) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683626) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683597) nascent E [endoplasmic reticulum lumen] (R-COV-9683684) Ub-3xPalmC-E [Golgi membrane] (R-COV-9683694) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698721) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698722) Ub-3xPalmC-E [virion membrane] (R-COV-9698716)	0.573	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.557	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.544	2
UniProt:O75569 PRKRA	2	PRKRA [cytosol] (R-HSA-2399897) p-S246,S287-PRKRA [cytosol] (R-HSA-9834791)	0.537	6
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:Q9BQ75 CMS1			0.527	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.527	2
UniProt:O75683 SURF6			0.527	2
UniProt:Q8NCA5 FA98A			0.527	2
UniProt:Q13310 PABP4			0.527	2
UniProt:P16989 YBOX3			0.527	2
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.524	2
UniProt:P84025	9	Ub-SMAD3 [cytosol] (R-RNO-6782830) phospho-p-S208-SMAD3 [cytosol] (R-RNO-9731114) SMAD3 [nucleoplasm] (R-RNO-206150) phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-RNO-2187326) phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-RNO-9773841) phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (R-RNO-2176471) SMAD3 [cytosol] (R-RNO-170855) phospho-p-S423,S425-SMAD3 [cytosol] (R-RNO-171184) phospho-p-S423,S425-SMAD3 [nucleoplasm] (R-RNO-177104)	0.524	4
IntAct:EBI-5590670 PGH2			0.524	5
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.463	2

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