Reactome | pp1a-nsp6-11 [cytosol]

pp1a-nsp6-11 [cytosol]

Stable Identifier

R-COV-9684354

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:P0C6U8 1a

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External Reference Information

External Reference

UniProt:P0C6U8 1a

Gene Names

Chain

chain:1-4382, chain:1-180, chain:181-818, chain:819-2740, chain:2741-3240, chain:3241-3546, chain:3547-3836, chain:3837-3919, chain:3920-4117, chain:4118-4230, chain:4231-4369, chain:4370-4382

Participates

as an input of

3CLp cleaves nsp6-11 (Homo sapiens)

as an output of

This entity regulates

Positively

Enhanced autophagosome formation (Homo sapiens)

Other forms of this molecule

N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]

pp1a-nsp4 [cytosol]

pp1a-nsp3 [cytosol]

pp1a-nsp11 [cytosol]

pp1a-nsp6 [endoplasmic reticulum membrane]

pp1a-nsp9 [cytosol]

pp1a [cytosol]

pp1a-nsp5 [cytosol]

pp1a-nsp2 [cytosol]

pp1a-nsp1 [cytosol]

pp1a-nsp1-4 [cytosol]

N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]

pp1a-nsp3-4 [cytosol]

pp1a-nsp6 [double membrane vesicle viral factory outer membrane]

pp1a-nsp4 [double membrane vesicle viral factory outer membrane]

pp1a-nsp3 [double membrane vesicle viral factory outer membrane]

pp1a-nsp7 [cytosol]

pp1a-nsp8 [cytosol]

pp1a-nsp10 [cytosol]

N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]

Inferred To

pp1a-nsp6-11 [cytosol] (Severe acute respiratory syndrome coronavirus 2)

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

ZINC - Investigational

R1A_CVHSA

ZINC - Metabolites

R1A_CVHSA

IntEnz

3.4.22.69

ZINC - Substances

R1A_CVHSA

ZINC target

P0C6U8

ZINC - Biogenic

R1A_CVHSA

ZINC - Predictions - Purchasable

R1A_CVHSA

PDB

3M3S, 2LIZ, 6XHL, 3M3V, 2GA6, 6Y7M, 6LNY, 2AMQ, 2AJ5, 2BX4, 1Z1I, 2ZU4, 2GDT, 1QZ8, 3V3M, 2A5K, 2W2G, 2GRI, 3EA7, 3VB3, 1Q1X, 1UW7, 1UK2, 2HSX, 2ACF, 2H2Z, 3F9G, 2HOB, 3SND, 3TIT, 3F9E, 2GZ8, 3SNA, 1Q2W, 3EAJ, 3TNS, 6LO0, 4MDS, 2KQV, 1UK3, 2PWX, 3VB6, 3AW0, 2GTB, 2Z3D, 2D2D, 2A5A, 3IWM, 2GX4, 6NUR, 2GT7, 6XHN, 2C3S, 6W2A, 4M0W, 2ALV, 1YSY, 3SNB, 3M3T, 2OP9, 3ATW, 1P9T, 1UJ1, 2ZU5, 4OVZ, 2BX3, 1Z1J, 4OW0, 4HI3, 2A5I, 3E91, 2G9T, 3VB4, 3EA8, 2KYS, 2DUC, 1PA5, 6NUS, 3SNC, 2GZ7, 3TIU, 3SZN, 3SNE, 6XHO, 2IDY, 2GZ9, 3F9F, 5Y3E, 3R24, 2WCT, 3VB7, 3AVZ, 2AHM, 3SN8, 1WOF, 3MJ5, 2KQW, 1UK4, 3TNT, 2FYG, 2KAF, 3EA9, 3AW1, 3VB5, 4MM3, 3EE7, 2FE8, 3F9H, 2AMD, 1P76, 2Z3E, 1PUK, 5Y3Q, 3FZD, 5F22, 2Z3C, 2GT8, 2FAV

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0C6U8 1a	21	pp1a-nsp4 [cytosol] (R-COV-9684342) N-glycan pp1a-nsp4 [endoplasmic reticulum membrane] (R-COV-9684271) pp1a-nsp3 [cytosol] (R-COV-9684257) pp1a-nsp11 [cytosol] (R-COV-9678271) pp1a-nsp6 [endoplasmic reticulum membrane] (R-COV-9678265) pp1a-nsp9 [cytosol] (R-COV-9678273) pp1a-nsp6-11 [cytosol] (R-COV-9684354) pp1a [cytosol] (R-COV-9684357) pp1a-nsp5 [cytosol] (R-COV-9678259) pp1a-nsp2 [cytosol] (R-COV-9678250) pp1a-nsp1 [cytosol] (R-COV-9678243) pp1a-nsp1-4 [cytosol] (R-COV-9684311) N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane] (R-COV-9684267) pp1a-nsp3-4 [cytosol] (R-COV-9684263) pp1a-nsp6 [double membrane vesicle viral factory outer membrane] (R-COV-9686007) pp1a-nsp4 [double membrane vesicle viral factory outer membrane] (R-COV-9685995) pp1a-nsp3 [double membrane vesicle viral factory outer membrane] (R-COV-9686004) pp1a-nsp7 [cytosol] (R-COV-9678266) pp1a-nsp8 [cytosol] (R-COV-9678275) pp1a-nsp10 [cytosol] (R-COV-9678272) N-glycan pp1a-nsp3 [endoplasmic reticulum membrane] (R-COV-9678246)	0.558	6

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