complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]

Stable Identifier
R-COV-9694343
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Synonyms
P0DTC2
Locations in the PathwayBrowser
General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

Literature References
PubMed ID Title Journal Year
16122388 The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization

Chakraborti, S, Prabakaran, P, Xiao, X, Dimitrov, DS

Virol. J. 2005
12775768 Mass spectrometric characterization of proteins from the SARS virus: a preliminary report

Krokhin, O, Li, Y, Andonov, A, Feldmann, H, Flick, R, Jones, S, Stroeher, U, Bastien, N, Dasuri, KV, Cheng, K, Simonsen, JN, Perreault, H, Wilkins, J, Ens, W, Plummer, F, Standing, KG

Mol. Cell Proteomics 2003
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Ritchie, G, Harvey, DJ, Feldmann, F, Stroeher, U, Feldmann, H, Royle, L, Dwek, RA, Rudd, PM

Virology 2010
15253436 Proteomic analysis of SARS associated coronavirus using two-dimensional liquid chromatography mass spectrometry and one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by mass spectroemtric analysis

Zeng, R, Ruan, HQ, Jiang, XS, Zhou, H, Shi, L, Zhang, L, Sheng, QH, Tu, Q, Xia, QC, Wu, JR

J. Proteome Res. 2004
14760722 Proteomic analysis on structural proteins of Severe Acute Respiratory Syndrome coronavirus

Ying, W, Hao, Y, Zhang, Y, Peng, W, Qin, E, Cai, Y, Wei, K, Wang, J, Chang, G, Sun, W, Dai, S, Li, X, Zhu, Y, Li, J, Wu, S, Guo, L, Dai, J, Wang, J, Wan, P, Chen, T, Du, C, Li, D, Wan, J, Kuai, X, Li, W, Shi, R, Wei, H, Cao, C, Yu, M, Liu, H, Dong, F, Wang, D, Zhang, X, Qian, X, Zhu, Q, He, F

Proteomics 2004
17715238 Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry

Han, DP, Lohani, M, Cho, MW

J. Virol. 2007
External Reference Information
External Reference
Gene Names
S, 2
Chain
signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273
Reference Transcript
Participates
Other forms of this molecule
Inferred From
Modified Residues
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1098
Coordinate
1098
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1134
Coordinate
1134
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1173
Coordinate
1173
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1158
Coordinate
1158
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1194
Coordinate
1194
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Interactors (28)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.995 150
 UniProt:P0DTC2 S  16 0.971 34
 UniProt:P09958 FURIN  4 0.854 5
 UniProt:Q9NNX6 CD209  1 0.766 6
 UniProt:Q9H2X3 CLC4M      0.71 5
 UniProt:Q96D42 HAVR1      0.667 7
 UniProt:P30530 AXL  2 0.655 9
 UniProt:P35613 BSG  2 0.652 7
 IntAct:EBI-26657218 PEPTIDE      0.645 7
 UniProt:Q9C0B5 ZDHC5      0.643 3
 UniProt:Q7Z5G4 GOLGA7  3 0.643 3
 UniProt:O14786 NRP1  1 0.639 9
 ChEBI:28304 HEPARIN      0.623 5
 UniProt:Q96LC7 SIGLEC10  1 0.623 2
 UniProt:P07711 CTSL  8 0.623 3
 UniProt:Q8IUN9 CLEC10A  1 0.623 4
 cholesterol [ChEBI:16113]  20 0.558 5
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 UniProt:Q8IUN9-2 CLEC10A      0.558 3
 UniProt:Q61830 Mrc1  4 0.558 2
 UniProt:P01130 LDLR  4 0.537 4
 UniProt:P00533 EGFR  59 0.537 4
 IntAct:EBI-26657222 PEPTIDE      0.525 2
 IntAct:EBI-26657225 PEPTIDE      0.525 2
 linoleic acid [ChEBI:17351]  6 0.522 2
 UniProt:P0DTD1-PRO_0000449625 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449627 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449628 REP      0.488 2
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