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O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
Stable Identifier
R-COV-9694386
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
Synonyms
P0DTC3
Locations in the PathwayBrowser for interactor UniProt:Q01518 CAP1
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of protein 3a (Homo sapiens)
O-glycosylation of 3a is terminated (Homo sapiens)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (Severe acute respiratory syndrome coronavirus 2)
Protein 3a forms a homotetramer (Homo sapiens)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (Severe acute respiratory syndrome coronavirus 2)
General
SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).
Literature References
PubMed ID
Title
Journal
Year
16474139
Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M
de Haan, CA
,
de Groot, RJ
,
Oostra, M
,
Rottier, PJ
J. Virol.
2006
External Reference Information
External Reference
UniProt:P0DTC3 3a
Gene Names
3a
Chain
chain:1-275
Reference Genes
BioGPS Gene:43740569 3a
Monarch:43740569 3a
NCBI Gene:43740569 3a
UCSC:P0DTC3 3a
Reference Transcript
RefSeq:NC_045512.2 3a
Participates
as an output of
O-glycosylation of 3a is terminated (Homo sapiens)
as an input of
Protein 3a forms a homotetramer (Homo sapiens)
as a component of
O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Severe acute respiratory syndrome coronavirus 2)
Other forms of this molecule
O-glycosyl 3a [virion membrane]
O-glycosyl 3a [endocytic vesicle membrane]
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
3a [endoplasmic reticulum-Golgi intermediate compartment]
3a [endoplasmic reticulum lumen]
O-glycosyl 3a [endolysosome membrane]
O-glycosyl 3a [plasma membrane]
O-glycosyl 3a [extracellular region]
Inferred From
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Human SARS coronavirus)
Modified Residues
Name
O-glycosyl-L-threonine at unknown position
PsiMod Name
O-glycosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine.
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
YP_009724391.1
GlyGen
P0DTC3
PDB
8EQU
,
6XDC
,
8EQT
,
8T5Q
,
8T5P
,
8EQJ
,
7KJR
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96JC1 VPS39
1
VPS39 [endosome membrane]
(R-HSA-2197806)
0.956
19
UniProt:Q96S66 CLCC1
0.875
9
UniProt:Q9H270 VPS11
1
VPS11 [endosome membrane]
(R-HSA-2197802)
0.823
7
UniProt:Q9Y673 ALG5
1
ALG5 [endoplasmic reticulum membrane]
(R-HSA-532211)
0.738
4
UniProt:P09601 HMOX1
4
HMOX1 [cytosol]
(R-HSA-9609901)
HMOX1 [endoplasmic reticulum membrane]
(R-HSA-189395)
HMOX1 [mitochondrial outer membrane]
(R-HSA-9708524)
HMOX1 [nucleoplasm]
(R-HSA-9708567)
0.738
4
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.716
4
UniProt:P49754 VPS41
1
VPS41 [endosome membrane]
(R-HSA-2197800)
0.695
4
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.659
3
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.659
3
UniProt:Q8N6S5 AR6P6
0.643
3
UniProt:Q8IWR1 TRI59
0.643
3
UniProt:Q01518 CAP1
3
CAP1 [azurophil granule lumen]
(R-HSA-6798752)
CAP1 [extracellular region]
(R-HSA-350746)
CAP1 [cytosol]
(R-HSA-350758)
0.613
3
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.602
6
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.602
4
UniProt:P51809 VAMP7
6
VAMP7 [late endosome membrane]
(R-HSA-2193120)
VAMP7 [lysosomal membrane]
(R-HSA-376342)
VAMP7 [plasma membrane]
(R-HSA-376361)
VAMP7 [Golgi membrane]
(R-HSA-266197)
VAMP7 [cytoplasmic vesicle membrane]
(R-HSA-376336)
VAMP7 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869135)
0.602
4
UniProt:Q96HE7 ERO1A
1
ERO1L [endoplasmic reticulum lumen]
(R-HSA-265076)
0.547
2
UniProt:P07205 PGK2
1
PGK2 [cytosol]
(R-HSA-6807622)
0.547
2
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.547
2
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.547
2
UniProt:Q8NBS9 TXNDC5
4
TXNDC5 [Golgi lumen]
(R-HSA-434325)
TXNDC5 [lysosomal lumen]
(R-HSA-429813)
TXNDC5 [extracellular region]
(R-HSA-6806246)
TXNDC5 [azurophil granule lumen]
(R-HSA-6799367)
0.547
2
UniProt:Q92545 TM131
0.547
2
UniProt:Q9H0V9 LMAN2L
3
LMAN2L [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689834)
LMAN2L [ER to Golgi transport vesicle membrane]
(R-HSA-5689832)
LMAN2L [endoplasmic reticulum membrane]
(R-HSA-5689469)
0.547
2
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.527
2
UniProt:P51153 RAB13
4
GGC-RAB13 [cytoplasmic vesicle membrane]
(R-HSA-1445110)
GGC-RAB13 [cell junction]
(R-HSA-8876591)
GGC-RAB13 [cytosol]
(R-HSA-8873767)
RAB13 [cytosol]
(R-HSA-8873674)
0.527
2
UniProt:Q15005 SPCS2
1
SPCS2 [endoplasmic reticulum membrane]
(R-HSA-264996)
0.527
2
UniProt:Q9Y4P3 TBL2
0.527
2
UniProt:Q9NRX4 PHP14
0.527
2
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.527
2
UniProt:P61106 RAB14
7
GGC-RAB14 [cytoplasmic vesicle membrane]
(R-HSA-1445086)
GGC-RAB14 [recycling endosome membrane]
(R-HSA-8876593)
GGC-RAB14 [cytosol]
(R-HSA-8873763)
RAB14 [cytosol]
(R-HSA-8873701)
RAB14 [early endosome membrane]
(R-HSA-8871372)
RAB14 [plasma membrane]
(R-HSA-6806438)
RAB14 [tertiary granule membrane]
(R-HSA-6800407)
0.527
2
UniProt:Q9UNN8 PROCR
2
PROCR(18-?) [extracellular region]
(R-HSA-5610109)
PROCR [plasma membrane]
(R-HSA-5591027)
0.527
2
UniProt:P30519 HMOX2
3
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
HMOX2 [plasma membrane]
(R-HSA-6799676)
0.527
2
UniProt:P04439 HLA-A
9
HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983100)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane]
(R-HSA-983376)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane]
(R-HSA-197642)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983347)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane]
(R-HSA-1236826)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863889)
HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236740)
HLA-A A-3 [endoplasmic reticulum membrane]
(R-HSA-8943090)
K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943073)
0.527
2
UniProt:O75976 CPD
3
CPD [Golgi membrane]
(R-HSA-432675)
CPD [cytoplasmic vesicle membrane]
(R-HSA-432671)
CPD [plasma membrane]
(R-HSA-9715182)
0.527
2
UniProt:P0DTD8 NS7B
0.519
3
UniProt:Q8NAF0 ZN579
0.499
2
UniProt:P0DTD1-PRO_0000449632 REP
0.488
2
UniProt:Q9P253 VPS18
1
VPS18 [endosome membrane]
(R-HSA-2197799)
0.483
2
UniProt:Q8NHV4 NEDD1
1
NEDD1 [cytosol]
(R-HSA-379267)
0.483
2
UniProt:Q9H269 VPS16
1
VPS16 [endosome membrane]
(R-HSA-2197803)
0.483
2
UniProt:Q12913 PTPRJ
2
PTPRJ [specific granule membrane]
(R-HSA-6799570)
PTPRJ [plasma membrane]
(R-HSA-6785269)
0.483
2
UniProt:P42765 ACAA2
1
ACAA2 [mitochondrial matrix]
(R-HSA-8874752)
0.482
2
UniProt:Q9H3K2 GHITM
0.482
2
UniProt:Q96GS4 BORC6
0.463
2
UniProt:Q9GZU1 MCOLN1
2
MCOLN1 [plasma membrane]
(R-HSA-3211764)
MCOLN1 [endosome membrane]
(R-HSA-917803)
0.463
2
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