Reactome | 3a [endoplasmic reticulum lumen]

3a [endoplasmic reticulum lumen]

Stable Identifier

R-COV-9694584

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endoplasmic reticulum lumen

Synonyms

P0DTC3

Locations in the PathwayBrowser for interactor UniProt:Q12913 PTPRJ

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External Reference Information

External Reference

UniProt:P0DTC3 3a

Gene Names

Chain

chain:1-275

Reference Genes

BioGPS Gene:43740569 3a

KEGG Gene (Hepatitis C Virus):43740569 3a

KEGG Gene (Viruses):43740569 3a

Monarch:43740569 3a

NCBI Gene:43740569 3a

Reference Transcript

RefSeq:NC_045512.2 3a

Participates

as an output of

mRNA3 is translated to protein 3a (Homo sapiens)

as an input of

3a translocates to the ERGIC (Homo sapiens)

Other forms of this molecule

O-glycosyl 3a [extracellular region]

O-glycosyl 3a [plasma membrane]

O-glycosyl 3a [endolysosome membrane]

3a [endoplasmic reticulum-Golgi intermediate compartment]

GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]

O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]

O-glycosyl 3a [endocytic vesicle membrane]

O-glycosyl 3a [virion membrane]

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

RefSeq

YP_009724391.1

PDB

6XDC, 7KJR

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC1 VPS39	1	VPS39 [endosome membrane] (R-HSA-2197806)	0.946	15
UniProt:Q96S66 CLCC1			0.836	8
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.773	6
UniProt:P49754 VPS41	1	VPS41 [endosome membrane] (R-HSA-2197800)	0.695	4
UniProt:Q8IWR1 TRI59			0.643	3
UniProt:Q8N6S5 AR6P6			0.643	3
UniProt:Q9Y673 ALG5	1	ALG5 [endoplasmic reticulum membrane] (R-HSA-532211)	0.643	3
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.643	3
UniProt:Q9P2Y5 UVRAG	2	UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510) UVRAG [cytosol] (R-HSA-5668884)	0.602	6
UniProt:P0DTC3 3a	9	O-glycosyl 3a [extracellular region] (R-COV-9694387) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) 3a [endoplasmic reticulum lumen] (R-COV-9694584) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [virion membrane] (R-COV-9694395)	0.529	2
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.527	2
UniProt:P61106 RAB14	7	GGC-RAB14 [cytoplasmic vesicle membrane] (R-HSA-1445086) GGC-RAB14 [recycling endosome membrane] (R-HSA-8876593) GGC-RAB14 [cytosol] (R-HSA-8873763) RAB14 [cytosol] (R-HSA-8873701) RAB14 [early endosome membrane] (R-HSA-8871372) RAB14 [plasma membrane] (R-HSA-6806438) RAB14 [tertiary granule membrane] (R-HSA-6800407)	0.527	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.527	2
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.527	2
UniProt:Q9Y4P3 TBL2			0.527	2
UniProt:P51153 RAB13	4	GGC-RAB13 [cytoplasmic vesicle membrane] (R-HSA-1445110) GGC-RAB13 [cell junction] (R-HSA-8876591) GGC-RAB13 [cytosol] (R-HSA-8873767) RAB13 [cytosol] (R-HSA-8873674)	0.527	2
UniProt:Q9UNN8 PROCR	2	PROCR(18-?) [extracellular region] (R-HSA-5610109) PROCR [plasma membrane] (R-HSA-5591027)	0.527	2
UniProt:P0DTD1-PRO_0000449632 REP			0.488	2
UniProt:Q8NHV4 NEDD1	1	NEDD1 [cytosol] (R-HSA-379267)	0.483	2
UniProt:Q9H269 VPS16	1	VPS16 [endosome membrane] (R-HSA-2197803)	0.483	2
UniProt:Q9P253 VPS18	1	VPS18 [endosome membrane] (R-HSA-2197799)	0.483	2
UniProt:Q12913 PTPRJ	2	PTPRJ [specific granule membrane] (R-HSA-6799570) PTPRJ [plasma membrane] (R-HSA-6785269)	0.483	2

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