Reactome | 3a [endoplasmic reticulum-Golgi intermediate compartment]

3a [endoplasmic reticulum-Golgi intermediate compartment]

Stable Identifier

R-COV-9694716

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endoplasmic reticulum-Golgi intermediate compartment

Synonyms

P0DTC3

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
16474139	Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M Oostra, M, de Haan, CA, de Groot, RJ, Rottier, PJ	J. Virol.	2006

External Reference Information

External Reference

UniProt:P0DTC3 3a

Gene Names

Chain

chain:1-275

Reference Genes

BioGPS Gene:43740569 3a

KEGG Gene (Hepatitis C Virus):43740569 3a

Monarch:43740569 3a

NCBI Gene:43740569 3a

Reference Transcript

RefSeq:NC_045512.2 3a

Participates

as an output of

3a translocates to the ERGIC (Homo sapiens)

as an input of

GalNAc is transferred onto 3a (Homo sapiens)

Other forms of this molecule

3a [endoplasmic reticulum lumen]

O-glycosyl 3a [virion membrane]

GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]

O-glycosyl 3a [extracellular region]

O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]

O-glycosyl 3a [endocytic vesicle membrane]

O-glycosyl 3a [plasma membrane]

Inferred From

3a [endoplasmic reticulum-Golgi intermediate compartment] (Human SARS coronavirus)

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

RefSeq

YP_009724391.1

GlyGen

P0DTC3

PDB

7KJR, 6XDC

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC1 VPS39			0.916	13
UniProt:Q96S66 CLCC1			0.725	4
UniProt:Q8IWR1 TRI59			0.643	3
UniProt:Q9H270 VPS11			0.643	3
UniProt:P09601 HMOX1	4	HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.643	3
UniProt:Q8N6S5 AR6P6			0.643	3
UniProt:Q9Y673 ALG5	1	ALG5 [endoplasmic reticulum membrane] (R-HSA-532211)	0.643	3
UniProt:P49754 VPS41			0.623	3
UniProt:P61106 RAB14	7	GGC-RAB14 [recycling endosome membrane] (R-HSA-8876593) GGC-RAB14 [cytoplasmic vesicle membrane] (R-HSA-1445086) GGC-RAB14 [cytosol] (R-HSA-8873763) RAB14 [cytosol] (R-HSA-8873701) RAB14 [early endosome membrane] (R-HSA-8871372) RAB14 [plasma membrane] (R-HSA-6806438) RAB14 [tertiary granule membrane] (R-HSA-6800407)	0.527	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	2
UniProt:O75976 CPD	3	CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [Golgi membrane] (R-HSA-432675) CPD [plasma membrane] (R-HSA-9715182)	0.527	2
UniProt:P30519 HMOX2	3	HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.527	2
UniProt:Q9Y4P3 TBL2			0.527	2
UniProt:P51153 RAB13	4	GGC-RAB13 [cell junction] (R-HSA-8876591) GGC-RAB13 [cytoplasmic vesicle membrane] (R-HSA-1445110) GGC-RAB13 [cytosol] (R-HSA-8873767) RAB13 [cytosol] (R-HSA-8873674)	0.527	2
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.527	2
UniProt:Q9UNN8 PROCR	2	PROCR [plasma membrane] (R-HSA-5591027) PROCR(18-?) [extracellular region] (R-HSA-5610109)	0.527	2
UniProt:P0DTD1-PRO_0000449632 REP			0.488	2

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