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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
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Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
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COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
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high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
Stable Identifier
R-COV-9696880
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Spike translocates to ERGIC (Homo sapiens)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (Severe acute respiratory syndrome coronavirus 2)
Trimmed spike protein binds to calnexin (Homo sapiens)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (Severe acute respiratory syndrome coronavirus 2)
Literature References
PubMed ID
Title
Journal
Year
32366695
Site-specific glycan analysis of the SARS-CoV-2 spike
Watanabe, Y
,
Crispin, M
,
Allen, JD
,
McLellan, JS
,
Wrapp, D
Science
2020
External Reference Information
External Reference
UniProt:P0DTC2 S
Gene Names
S, 2
Chain
signal peptide:1-13, chain:14-1273, chain:14-685, chain:686-1273, chain:816-1273
Reference Genes
BioGPS Gene:43740568 S
Monarch:43740568 S
NCBI Gene:43740568 S
UCSC:P0DTC2 S
Reference Transcript
RefSeq:NC_045512.2 S
Participates
as an output of
Trimmed spike protein binds to calnexin (Homo sapiens)
as an input of
Spike translocates to ERGIC (Homo sapiens)
Other forms of this molecule
S(686-815) [plasma membrane]
Spike S2' Fragment [plasma membrane]
S1 [plasma membrane]
fully glycosylated Spike [plasma membrane]
nascent Spike [endoplasmic reticulum lumen]
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
fully glycosylated Spike [virion membrane]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1098
Coordinate
1098
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1134
Coordinate
1134
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1158
Coordinate
1158
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1173
Coordinate
1173
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1194
Coordinate
1194
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122
Coordinate
122
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 149
Coordinate
149
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 165
Coordinate
165
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 17
Coordinate
17
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 282
Coordinate
282
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 331
Coordinate
331
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 343
Coordinate
343
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603
Coordinate
603
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61
Coordinate
61
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 616
Coordinate
616
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 657
Coordinate
657
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
Coordinate
709
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
Coordinate
717
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 74
Coordinate
74
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234
Coordinate
234
Modification
Man(9) N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
YP_009724390.1
GlyGen
P0DTC2
PDB
7BNV
,
7R1A
,
7XSC
,
7XMX
,
7PBE
,
7KNH
,
8AQU
,
7L2D
,
7ORB
,
6XKQ
,
7XIK
,
7X94
,
7DWZ
,
7CH5
,
7WD7
,
7V7A
,
7KSG
,
7R13
,
7W9C
,
7WUH
,
7WA1
,
8VQR
,
7KE8
,
7RQ6
,
7KN6
,
7FDK
,
7EZV
,
7P5S
,
8R1D
,
7UPY
,
7F6Y
,
8IVA
,
7WSE
,
7SXY
,
7KFY
,
7FB0
,
8GNH
,
8DTT
,
6VSB
,
7OAY
,
7KDJ
,
7PQY
,
7K8M
,
7WP1
,
7V88
,
8CIN
,
7RNJ
,
7YTN
,
8GTP
,
7CZT
,
8DNN
,
8JYM
,
7YQZ
,
9FGU
,
7BEI
,
7NX8
,
6X79
,
7D4G
,
7N1F
,
7SBU
,
8SMI
,
7NDA
,
7ZJL
,
7M8J
,
7V77
,
8DLO
,
6ZP1
,
7ZSS
,
7MY2
,
7A5S
,
7Q9M
,
7YBH
,
6XRA
,
7Z0X
,
8HQT
,
8DM4
,
7R4I
,
7N8I
,
8G79
,
8J1Q
,
7M0J
,
7VNC
,
7N6E
,
7M6F
,
7PS5
,
7D03
,
7DZY
,
8CY7
,
7U9O
,
7DX8
,
7Y8J
,
7Y21
,
8EPP
,
7E9T
,
7EDI
,
7KXK
,
8HN6
,
8OWT
,
7Y7K
,
7Y0N
,
6XM3
,
8BG3
,
7FC5
,
7XU1
,
7WZ1
,
7SL5
,
7P7B
,
7NTA
,
7E86
,
7DET
,
7TP1
,
7SOC
,
7Y6N
,
8IX3
,
7WCH
,
7DX6
,
7MJM
,
7CHP
,
8ASY
,
7WHB
,
8RH6
,
8FEZ
,
8DV1
,
7W9B
,
7XEG
,
8DXT
,
7V7D
,
7KMI
,
8BBN
,
7V8B
,
7THE
,
7YV8
,
7KJ5
,
7WTJ
,
7SXR
,
7EYA
,
6Z2M
,
8DPZ
,
7SJ0
,
7TGE
,
8ELO
,
8ZC4
,
7T7B
,
8QTD
,
7WCZ
,
8VKO
,
7TCC
,
7T67
,
7RU2
,
7V86
,
7ND5
,
7DK4
,
7TP7
,
7WHH
,
8V0R
,
7F63
,
7ME7
,
7SY7
,
7URS
,
7MZK
,
8HC8
,
7E3O
,
7CZS
,
7VRV
,
7WK8
,
7LY3
,
6VW1
,
7UKL
,
7YVL
,
7CYV
,
7N3I
,
7ENF
,
7UB0
,
7X2L
,
7A5R
,
8G71
,
8CBE
,
8KC2
,
7XXL
,
8C3V
,
8SIT
,
7WPH
,
8CXN
,
7PKI
,
8KA8
,
7BEJ
,
7M6D
,
7PS6
,
8GB6
,
7N9B
,
8DI5
,
7DX0
,
8GF2
,
7Y75
,
7EJY
,
7DD8
,
7N8H
,
8CSJ
,
8DM2
,
7WNM
,
7LX5
,
7EDG
,
8HSM
,
7FAU
,
7WGV
,
8BG2
,
7EFP
,
8CWK
,
6LZG
,
7MM0
,
7TLD
,
8WLO
,
7R16
,
7DX9
,
8WRO
,
7SN3
,
7WWL
,
7MJK
,
7MF1
,
7FCQ
,
8BG6
,
7Y1Z
,
7KMH
,
8DXS
,
7WGY
,
7C8V
,
7V89
,
7TGX
,
8BEV
,
8JJE
,
7XOA
,
7KRR
,
8IV4
,
7S6J
,
8UUL
,
7FET
,
7WRZ
,
7SY1
,
7S83
,
7F5G
,
7W9F
,
7CAI
,
7CDI
,
7SIS
,
7KKK
,
8E1G
,
7WVP
,
7WD9
,
8DMA
,
7KN4
,
7NS6
,
7S5R
,
8GX9
,
7UL0
,
7SI2
,
8SK5
,
7DPM
,
7T72
,
8V0V
,
7YVG
,
7YR3
,
7C8D
,
7DMU
,
7LYL
,
7WK0
,
8H6F
,
7SWW
,
8GRY
,
7NXB
,
7YDI
,
8C89
,
7EAZ
,
8G75
,
7K8W
,
7LWO
,
8V0L
,
7EKG
,
7X1M
,
7CWN
,
7V83
,
7PS1
,
7D30
,
7TPA
,
8J26
,
7N64
,
8HPQ
,
7EB0
,
7M3I
,
7MW2
,
7QUR
,
7LQW
,
8IOS
,
8I4F
,
7M8U
,
6ZER
,
8WOY
,
7EJL
,
7ZCF
,
8DM8
,
7UHC
,
8XEA
,
7PHG
,
8A95
,
8I3U
,
7N1U
,
8BSF
,
7EJ5
,
7ZF3
,
8CYA
,
7BNO
,
6Z97
,
7MY3
,
8DF5
,
7DX7
,
7CN9
,
6X6P
,
7Y20
,
7UZD
,
7R4R
,
7RA8
,
7Y6D
,
7EDH
,
7CM4
,
7CHC
,
7SOB
,
8OWW
,
6XM4
,
7L7E
,
7WDF
,
6YZ5
,
7WZ2
,
7JZL
,
7QNY
,
7BZ5
,
7UZ7
,
7WS3
,
6XE1
,
6XCN
,
7TF1
,
8AQV
,
7XOC
,
7EY4
,
7CAC
,
7X92
,
7JJC
,
7K9I
,
7WG7
,
7L02
,
7VYR
,
7R11
,
7WVO
,
6XC3
,
7XIX
,
7XDA
,
7RKU
,
7VXI
,
7P79
,
7V7O
,
7JJI
,
7C53
,
8QSQ
,
7L4Z
,
7Z7X
,
7VX1
,
7SY6
,
7E3L
,
7V26
,
6ZWV
,
7KGJ
,
7YVH
,
7YQU
,
7WS1
,
7TP3
,
7X2H
,
8RBU
,
7A91
,
7EKC
,
7YUE
,
7CZW
,
7LAA
,
7YCO
,
7V81
,
8CMA
,
6ZGG
,
8I9F
,
8HHX
,
7WLC
,
7BEO
,
7NX9
,
7SBQ
,
6ZCZ
,
7XU4
,
8HFY
,
7LWV
,
8V0N
,
7MZN
,
7YH6
,
8DM6
,
7A4N
,
7UZA
,
8HPF
,
6ZP7
,
7LXY
,
7R95
,
7LDJ
,
8XE9
,
7DCC
,
8DM9
,
8C1V
,
8Q7S
,
8TAZ
,
7TPR
,
7RBU
,
8HRL
,
7RAQ
,
7N1W
,
8EQF
,
7JVA
,
7Z1D
,
7YC5
,
7ZF7
,
7KFV
,
7F6Z
,
7V27
,
7SY0
,
7EU2
,
8ELQ
,
7FAE
,
7UM2
,
7RZU
,
8GOM
,
7K9Z
,
7KDK
,
7JX3
,
7V7T
,
8CII
,
7WP6
,
7TOY
,
8V0T
,
8H5T
,
7YQW
,
7JV2
,
9FGR
,
7NX6
,
8HC5
,
7CZU
,
7DJZ
,
7YE5
,
7NDB
,
8EDF
,
8G72
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7KJ4
,
7S0E
,
7QF0
,
7F5R
,
7WSC
,
7UOW
,
7CAN
,
8ZC3
,
7OAU
,
6XEY
,
7RZV
,
8VYF
,
7WBL
,
7KDI
,
8RCV
,
7RU5
,
7ND8
,
7V7U
,
8U1G
,
7TOV
,
7AKD
,
7DK0
,
7WHJ
,
7SXV
,
7WO4
,
9FGS
,
8H5C
,
7N1A
,
6VYB
,
7YEG
,
7SBS
,
8G70
,
8DLM
,
6WPS
,
7YVO
,
7LY2
,
7R8L
,
7X2K
,
8GB5
,
8UK1
,
7Q9K
,
8HED
,
7YDY
,
8D8R
,
7MKB
,
7LWP
,
7VHJ
,
8C0Y
,
7TPH
,
9AYX
,
7VMU
,
7ZR2
,
7Q3R
,
7WOB
,
7YBN
,
8FU8
,
8SIQ
,
7K43
,
7WOC
,
6ZP5
,
7SC1
,
8DAD
,
8HPU
,
8HLD
,
6YZ7
,
8V0Q
,
8T20
,
7DHX
,
7M8S
,
7ZFD
,
8DLU
,
7N5H
,
7E9P
,
6X29
,
7LSS
,
8CYD
,
7M7W
,
7Q0I
,
7UB5
,
8DLX
,
8GB0
,
8G7B
,
7D0B
,
7MSQ
,
8K5G
,
7DEO
,
7X8Y
,
7N1V
,
7WOG
,
7F0X
,
7ZF9
,
7PR0
,
7ZR9
,
7U0Q
,
7DWX
,
7R19
,
7SN2
,
8BG5
,
7Y1Y
,
7CHH
,
7WWK
,
7MJJ
,
7X66
,
7V78
,
8QRF
,
7NT9
,
7Y0W
,
7WHD
,
7KMG
,
7QNW
,
7JZU
,
7KJ3
,
7S6L
,
7L3N
,
7L0N
,
8ELJ
,
7RW2
,
7F5H
,
7VXF
,
6M1V
,
7CAK
,
7WGB
,
7SY4
,
8FHY
,
7TEX
,
7OAO
,
7T5O
,
7RZT
,
8VKN
,
7WBH
,
8HXJ
,
7KMS
,
7V7H
,
7RU3
,
8TMA
,
8CMB
,
7DK3
,
7TP8
,
8UUO
,
8V0X
,
8GS6
,
7YVF
,
8XLN
,
7SY8
,
7LYO
,
8GPY
,
7KGK
,
7SBK
,
7F3Q
,
7NXA
,
7PRZ
,
7K8V
,
8I5I
,
8KHD
,
7CWM
,
8G74
,
7LWN
,
7D2Z
,
6ZDG
,
7EB5
,
8VKL
,
7V7R
,
8JYP
,
7PS0
,
7NX7
,
7N1B
,
8C8P
,
8HLC
,
7N4J
,
7MEJ
,
8HRD
,
7SBT
,
8DLI
,
7NDC
,
7LWM
,
8T23
,
7A96
,
8HFZ
,
6ZOZ
,
7U8E
,
7LXX
,
7MZF
,
7PS4
,
7YBK
,
7MXP
,
7YJ3
,
7TLT
,
8DM3
,
8G78
,
8TYO
,
7BEL
,
7DZX
,
7U0D
,
7M6I
,
7TPE
,
8CY9
,
8F2J
,
7VNB
,
7Z1C
,
7N9A
,
7KXJ
,
8GZZ
,
7THK
,
7R4Q
,
8EPQ
,
7VQ0
,
8F0G
,
7MJI
,
7DDN
,
7WGX
,
7Y72
,
7W99
,
7L7D
,
7FCE
,
8FDW
,
7MFU
,
7XU0
,
7OD3
,
8DW3
,
7UZ6
,
7WS6
,
8ZC0
,
7L2F
,
7XOB
,
8DT3
,
7XDL
,
7T9J
,
7WG9
,
7TF4
,
7OAP
,
7L09
,
7WCR
,
7X7N
,
7E7D
,
7TAT
,
6XC4
,
7VXK
,
8D0Z
,
7KN5
,
6M17
,
7WB5
,
7Z86
,
7KEB
,
7W94
,
7SXU
,
8XLM
,
7LYQ
,
7SWN
,
8H3E
,
7ND4
,
7WRJ
,
8IF2
,
8CMH
,
7YVK
,
6W41
,
7K8Z
,
7YCL
,
7TOU
,
7EKF
,
7A92
,
7JW0
,
7CZV
,
8I9C
,
7LAB
,
7CWL
,
7V7P
,
7E3C
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYF1 ACE2
5
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
0.997
242
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
0.986
60
UniProt:Q9C0B5 ZDHHC5
1
ZDHHC5 [Golgi membrane]
(R-HSA-9766353)
0.864
8
UniProt:Q9H2X3 CLEC4M
1
CLEC4M [plasma membrane]
(R-HSA-1472862)
0.857
12
UniProt:P09958 FURIN
6
FURIN [Golgi membrane]
(R-HSA-157049)
FURIN [extracellular region]
(R-HSA-1181103)
FURIN [plasma membrane]
(R-HSA-2159856)
FURIN [Golgi lumen]
(R-HSA-448351)
FURIN [trans-Golgi network membrane]
(R-HSA-9832627)
FURIN [macropinosome membrane]
(R-HSA-9837714)
0.854
5
UniProt:Q9NNX6 CD209
1
CD209 [plasma membrane]
(R-HSA-2079928)
0.848
11
UniProt:Q7Z5G4 GOLGA7
3
GOLGA7 [Golgi membrane]
(R-HSA-9647777)
GOLGA7 [tertiary granule lumen]
(R-HSA-6800164)
GOLGA7 [extracellular region]
(R-HSA-6800449)
0.817
7
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.746
8
UniProt:Q8R0I0
1
ACE2(18-805) [plasma membrane]
(R-MMU-2022344)
0.688
4
UniProt:Q8IUN9-2 CLEC10A
0.683
4
UniProt:P35247-PRO_0000017465 SFTPD
0.683
11
UniProt:Q96D42 HAVCR1
1
HAVCR1 [plasma membrane]
(R-HSA-5660386)
0.667
7
UniProt:Q96L92 SNX27
0.664
16
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.655
9
UniProt:P35613 BSG
2
BSG [plasma membrane]
(R-HSA-197673)
BSG [Golgi membrane]
(R-HSA-204478)
0.652
7
IntAct:EBI-26657218 PEPTIDE
0.645
7
ChEBI:17033 BILIVERDIN
0.642
9
UniProt:Q58DD0 ACE2
0.641
3
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.639
9
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.636
8
UniProt:P11226-PRO_0000017401 MBL2
0.632
11
maltose [ChEBI:17306]
2
Mal [cytosol]
(R-ALL-868706)
Mal [extracellular region]
(R-ALL-188986)
0.623
3
ChEBI:28304 HEPARIN
0.623
5
UniProt:P07711 CTSL
8
CTSL(292-333) [endocytic vesicle lumen]
(R-HSA-9686680)
CTSL(114-288) [endocytic vesicle lumen]
(R-HSA-9686686)
CTSL(114-288) [endolysosome lumen]
(R-HSA-1679050)
CTSL(292-333) [endolysosome lumen]
(R-HSA-1679026)
CTSL1(114-288) [early endosome lumen]
(R-HSA-4127474)
CTSL1(114-288) [lysosomal lumen]
(R-HSA-1181225)
CTSL(292-333) [extracellular region]
(R-HSA-449863)
CTSL(114-288) [extracellular region]
(R-HSA-449861)
0.623
3
UniProt:P59665-PRO_0000006773 DEFA1
0.618
3
UniProt:A5CKE2 A5CKE2
0.618
3
UniProt:P31431 SDC4
20
HS(4)-SDC4 [plasma membrane]
(R-HSA-2076670)
HS(6)-SDC4 [plasma membrane]
(R-HSA-2076633)
HS(2)-SDC4 [plasma membrane]
(R-HSA-2076694)
HS(1)-SDC4 [plasma membrane]
(R-HSA-2076653)
HS(3)-SDC4 [plasma membrane]
(R-HSA-2076674)
HS(5)-SDC4 [plasma membrane]
(R-HSA-2076635)
XylS-SDC4 [Golgi lumen]
(R-HSA-2064195)
Gal-Xyl-SDC4 [Golgi lumen]
(R-HSA-2064249)
SDC4 [Golgi lumen]
(R-HSA-2054111)
Gal-Gal-Xyl-SDC4 [Golgi lumen]
(R-HSA-2064100)
GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen]
(R-HSA-2064067)
HS(3)-SDC4 [Golgi lumen]
(R-HSA-2076418)
HS(4)-SDC4 [Golgi lumen]
(R-HSA-2076407)
HS(2)-SDC4 [Golgi lumen]
(R-HSA-2076411)
HS(1)-SDC4 [Golgi lumen]
(R-HSA-2076434)
Heparan(4)-SDC4 [Golgi lumen]
(R-HSA-2076613)
Heparan(3)-SDC4 [Golgi lumen]
(R-HSA-2076460)
Heparan(2)-SDC4 [Golgi lumen]
(R-HSA-2076446)
Heparan(1)-SDC4 [Golgi lumen]
(R-HSA-2076394)
Heparan-SDC4 [Golgi lumen]
(R-HSA-2076374)
0.599
17
hemin [ChEBI:50385]
1
hemin [cytosol]
(R-ALL-421489)
0.59
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.59
2
IntAct:EBI-27090397 RC-101
0.558
2
N-acetylneuraminic acid [ChEBI:17012]
1
Neu5Ac [Golgi lumen]
(R-ALL-975925)
0.558
2
UniProt:Q07021-PRO_0000018590 C1QBP
0.558
2
UniProt:Q61830 Mrc1
4
Mrc1 [plasma membrane]
(R-MMU-1236776)
Mrc1 [plasma membrane]
(R-MMU-1216515)
Mrc1 [clathrin-coated endocytic vesicle membrane]
(R-MMU-1236818)
Mrc1 [early endosome membrane]
(R-MMU-1236785)
0.558
2
lipopolysaccharide [ChEBI:16412]
5
LPS [endocytic vesicle lumen]
(R-ALL-2239413)
LPS [peptidoglycan-based cell wall]
(R-ALL-6803081)
LPS [endosome lumen]
(R-ALL-2201311)
LPS [plasma membrane]
(R-ALL-433850)
LPS [extracellular region]
(R-ALL-166005)
0.558
3
cholesterol [ChEBI:16113]
20
CHOL [lipid droplet]
(R-ALL-163586)
CHOL [early endosome]
(R-ALL-2429660)
CHOL [mitochondrial matrix]
(R-ALL-193840)
CHOL [cornified envelope]
(R-ALL-8847704)
cholesterol [mitochondrial intermembrane space]
(R-ALL-196084)
CHOL [mitochondrial outer membrane]
(R-ALL-8951853)
CHOL [mitochondrial inner membrane]
(R-ALL-193156)
CHOL [lysosomal membrane]
(R-ALL-8876478)
cholesterol [endosome lumen]
(R-ALL-171083)
cholesterol [endosome membrane]
(R-ALL-171135)
cholesterol [clathrin-coated endocytic vesicle membrane]
(R-ALL-171069)
CHOL [endoplasmic reticulum lumen]
(R-ALL-174672)
CHOL [smooth endoplasmic reticulum]
(R-ALL-8866305)
CHOL [transport vesicle membrane]
(R-ALL-216762)
CHOL [lysosomal lumen]
(R-ALL-8848047)
CHOL [cytosol]
(R-ALL-176478)
cholesterol [endocytic vesicle lumen]
(R-ALL-2239405)
CHOL [plasma membrane]
(R-ALL-171095)
CHOL [endoplasmic reticulum membrane]
(R-ALL-193384)
CHOL [extracellular region]
(R-ALL-171149)
0.558
5
UniProt:P35247 SFTPD
3
SFTPD [endoplasmic reticulum membrane]
(R-HSA-5685278)
SFTPD [clathrin-coated endocytic vesicle]
(R-HSA-5686343)
SFTPD [extracellular region]
(R-HSA-391099)
0.544
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.537
4
UniProt:P01130 LDLR
4
LDLR [plasma membrane]
(R-HSA-171053)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [endolysosome membrane]
(R-HSA-6784818)
0.537
4
UniProt:P60660 MYL6
2
p-S20-MYL6 [cytosol]
(R-HSA-445778)
MYL6 [cytosol]
(R-HSA-419186)
0.527
2
UniProt:Q9ULV4 COR1C
0.527
2
UniProt:Q9NYL9 TMOD3
1
TMOD3 [cytosol]
(R-HSA-217354)
0.527
2
IntAct:EBI-26657222 PEPTIDE
0.525
2
IntAct:EBI-26657225 PEPTIDE
0.525
2
IntAct:EBI-26997889 ACE2
0.524
2
UniProt:A0A1S3APE5 A0A1S3APE5
0.524
2
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.524
4
UniProt:Q5EGZ1
1
ACE2(18-805) [plasma membrane]
(R-RNO-2022344)
0.524
2
UniProt:E2DHI3 E2DHI3
0.524
2
UniProt:Q14416 GRM2
1
GRM2 [plasma membrane]
(R-HSA-420468)
0.524
4
linoleic acid [ChEBI:17351]
6
LINA [endoplasmic reticulum lumen]
(R-ALL-2046044)
LINA [early endosome]
(R-ALL-879655)
LINA [cytosol]
(R-ALL-1132021)
LINA [extracellular region]
(R-ALL-879520)
LINA [lipid droplet]
(R-ALL-2864095)
LINA [nucleoplasm]
(R-ALL-400158)
0.522
2
UniProt:P35606 COPB2
4
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [Golgi membrane]
(R-HSA-6808739)
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [cytosol]
(R-HSA-199972)
0.499
3
UniProt:Q9Y5S1 TRPV2
1
TRPV2 [plasma membrane]
(R-HSA-2671909)
0.499
2
UniProt:Q5EA32
1
TRPV2 [plasma membrane]
(R-BTA-2671909)
0.499
3
UniProt:Q5MNZ6 WDR45B
1
WDR45B [cytosol]
(R-HSA-5678303)
0.499
4
UniProt:Q15005 SPCS2
1
SPCS2 [endoplasmic reticulum membrane]
(R-HSA-264996)
0.499
2
UniProt:Q15436 SEC23A
4
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
0.499
20
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.499
20
UniProt:P0DTD1-PRO_0000449625 REP
0.488
2
UniProt:P0DTD1-PRO_0000449627 REP
0.488
2
UniProt:P0DTD1-PRO_0000449628 REP
0.488
2
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.483
10
UniProt:P14649 MYL6B
2
p-S20-MYL6B [cytosol]
(R-HSA-445763)
MYL6B [cytosol]
(R-HSA-445776)
0.482
2
UniProt:Q8WXE9 STON2
2
NEDD8-STON2 [cytosol]
(R-HSA-8863733)
STON2 [cytosol]
(R-HSA-8862856)
0.482
2
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