Reactome | M [plasma membrane]

M [plasma membrane]

Stable Identifier

R-COV-9755780

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

plasma membrane

Synonyms

P0DTC5

Locations in the PathwayBrowser

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General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

External Reference Information

External Reference

UniProt:P0DTC5 M

Gene Names

Chain

chain:1-222

Participates

as an input of

SARS-CoV-2 M, N bind to PDPK1 (Homo sapiens)

as a component of

N:M:PDPK1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

N-glycan M [virion membrane]

M [virion membrane]

M [endocytic vesicle membrane]

N-glycan M [endocytic vesicle membrane]

M [endoplasmic reticulum-Golgi intermediate compartment membrane]

N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]

M [endoplasmic reticulum membrane]

nascent M [endoplasmic reticulum lumen]

N-glycan M [endoplasmic reticulum membrane]

Inferred From

M [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

PDB

8CME, 7VGS, 8CTK, 7VGR

Interactors (59)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.733	11
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.681	10
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.674	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.674	6
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.665	4
UniProt:O75439 PMPCB	1	PMPCB [mitochondrial matrix] (R-HSA-1299434)	0.643	3
UniProt:Q96HW7 INTS4	1	INTS4 [nucleoplasm] (R-HSA-6807462)	0.643	3
UniProt:Q00765 REEP5			0.643	3
UniProt:Q96D53 COQ8B	1	COQ8B [mitochondrial inner membrane] (R-HSA-9856289)	0.643	3
UniProt:Q5JRX3 PITRM1	1	PITRM1 [mitochondrial matrix] (R-HSA-8986159)	0.643	3
UniProt:P05026 ATP1B1	1	ATP1B1 [plasma membrane] (R-HSA-375071)	0.643	3
UniProt:Q9NQC3 RTN4	1	RTN4 [plasma membrane] (R-HSA-194556)	0.643	3
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.621	3
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.573	4
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.553	2
UniProt:Q86UA1 PRP39			0.547	2
UniProt:Q9C029 TRIM7			0.547	2
UniProt:Q96RQ1 ERGI2			0.547	2
UniProt:O15063 GARRE1	1	KIAA0355 [cytosol] (R-HSA-9691200)	0.547	2
UniProt:Q96MT1 RN145			0.547	2
UniProt:Q9UI26 IPO11			0.547	2
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.547	2
UniProt:Q9UBQ6 EXTL2	1	EXTL2 [endoplasmic reticulum membrane] (R-HSA-8953372)	0.547	2
UniProt:O00482 NR5A2	1	NR5A2 [nucleoplasm] (R-HSA-9011735)	0.547	2
UniProt:Q96JB5 CK5P3			0.547	2
UniProt:P08236 GUSB	9	GUSB R611W [lysosomal lumen] (R-HSA-2318382) GUSB R216W [lysosomal lumen] (R-HSA-2318584) GUSB A354V [lysosomal lumen] (R-HSA-2318376) GUSB R356* [lysosomal lumen] (R-HSA-2318372) GUSB [lysosomal lumen] (R-HSA-1678846) GUSB [ficolin-1-rich granule lumen] (R-HSA-6800967) GUSB [extracellular region] (R-HSA-6806207) GUSB [azurophil granule lumen] (R-HSA-6799122) GUSB S52F [lysosomal lumen] (R-HSA-2318391)	0.547	2
IntAct:EBI-26608251 NC			0.541	4
UniProt:P11310 ACADM	1	ACADM [mitochondrial matrix] (R-HSA-49491)	0.527	2
UniProt:Q9UBU6 FA8A1			0.527	2
UniProt:Q9Y6E2 5MP1			0.527	2
UniProt:Q9BSJ2 TUBGCP2	1	TUBGCP2 [cytosol] (R-HSA-379275)	0.527	2
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.527	2
UniProt:Q96CW5 TUBGCP3	1	TUBGCP3 [cytosol] (R-HSA-379276)	0.527	2
UniProt:Q6PML9 ZNT9			0.527	2
UniProt:Q9UDR5 AASS	1	AASS [mitochondrial matrix] (R-HSA-70924)	0.527	2
UniProt:P13804 ETFA	1	ETFA(1-?) [mitochondrial matrix] (R-HSA-169262)	0.527	2
UniProt:Q10713 PMPCA	1	PMPCA [mitochondrial matrix] (R-HSA-1299450)	0.527	2
UniProt:Q96HR9 REEP6			0.527	2
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.527	2
UniProt:Q9Y6D5 ARFGEF2	1	ARFGEF2 [cytosol] (R-HSA-391301)	0.527	2
UniProt:Q93084 ATP2A3	2	ATP2A3 [platelet dense tubular network membrane] (R-HSA-427902) ATP2A3 [endoplasmic reticulum membrane] (R-HSA-391965)	0.527	2
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.527	2
UniProt:Q8NEW0 ZNT7			0.527	2
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:Q4KMQ2 ANO6	3	ANO6 [specific granule membrane] (R-HSA-6799509) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [tertiary granule membrane] (R-HSA-6800903)	0.527	2
UniProt:Q9Y312 AAR2			0.527	2
UniProt:Q15758 SLC1A5	1	SLC1A5 [plasma membrane] (R-HSA-352376)	0.527	2
UniProt:Q7L8L6 FASTKD5	1	FASTKD5 [mitochondrial matrix] (R-HSA-9837206)	0.527	2
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.527	2
UniProt:P38435 GGCX	1	GGCX [endoplasmic reticulum membrane] (R-HSA-159860)	0.527	2
UniProt:Q9BW92 TARS2	1	TARS2(1-?) [mitochondrial matrix] (R-HSA-379590)	0.527	2
UniProt:Q9BQT8 SLC25A21	1	SLC25A21 [mitochondrial inner membrane] (R-HSA-372474)	0.527	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	2
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.527	2
UniProt:Q07021-PRO_0000018590 C1QBP			0.524	2
UniProt:P0DTD8 NS7B			0.519	4
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.483	2
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.463	3
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.463	2

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