Reactome | CCND1 [nucleoplasm]

CCND1 [nucleoplasm]

Stable Identifier

R-DDI-113832-2

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

Q8T2F2

Locations in the PathwayBrowser

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Cell Cycle (Dictyostelium discoideum)

- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
    - G1 Phase (Dictyostelium discoideum)
      - Cyclin D associated events in G1 (Dictyostelium discoideum)
        
        CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Dictyostelium discoideum)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        Cyclin D1:Cdk6 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Dictyostelium discoideum)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Dictyostelium discoideum)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Drug-mediated inhibition of CDK4/CDK6 activity (Dictyostelium discoideum)
        
        CDK4 inhibitors bind CDK4 (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK6 inhibitors bind CDK6 (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Dictyostelium discoideum)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Dictyostelium discoideum)
        
        CDK4:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        CDK4:CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK6:CCND [nucleoplasm] (Dictyostelium discoideum)
        
        Cyclin D1:Cdk6 [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)
        
        CCND1 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q8T2F2

Reference Genes

BioGPS Gene:8621043

dictyBase:DDB_G0277439

ENSEMBL:DDB_G0277439

KEGG Gene (Dictyostelium discoideum):DDB_G0277439

Monarch:8621043

NCBI Gene:8621043

Reference Transcript

RefSeq:XM_637534.1

Participates

as a member of

Homologues of CCND1 [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

PolyUb-CCNA2 [nucleoplasm]

phospho-p-T286-CCND1 [cytosol]

phospho-p-T286-CCND1 [nucleoplasm]

CCNF [cytosol]

CCND1 [cytosol]

CCND3 [cytosol]

CCND2 [cytosol]

CCND3 [nucleoplasm]

CCND2 [nucleoplasm]

CCNE2 [cytosol]

CCNE1 [cytosol]

CCNE2 [nucleoplasm]

CCNE1 [nucleoplasm]

CCNA2 [cytosol]

CCNA2 [nucleoplasm]

Inferred From

CCND1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_642626.1

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