Reactome | brk1 [cytosol]

brk1 [cytosol]

Stable Identifier

R-DDI-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

BRK1, Q54X65

Locations in the PathwayBrowser

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Immune System (Dictyostelium discoideum)

- Innate Immune System (Dictyostelium discoideum)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
    - Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
      - Detachment of WASP/WAVE (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
      - p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        brk1 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54X65

Gene Names

brk1

Reference Genes

BioGPS Gene:8621907 brk1

dictyBase:DDB_G0279175

ENSEMBL:DDB_G0279175

KEGG Gene (Dictyostelium discoideum):DDB_G0279175 brk1

Monarch:8621907 brk1

NCBI Gene:8621907 brk1

Reference Transcript

RefSeq:XM_636737.1 brk1

Participates

as a candidate of

as a component of

Inferred From

BRK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_641829.1

PRO

Q54X65

PDB

3PP5

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