Reactome | phospho-p-IRAK2 [cytosol]

phospho-p-IRAK2 [cytosol]

Stable Identifier

R-DDI-446636

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q54LU8

Locations in the PathwayBrowser

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Immune System (Dictyostelium discoideum)

- Cytokine Signaling in Immune system (Dictyostelium discoideum)
  - Signaling by Interleukins (Dictyostelium discoideum)
    - Interleukin-17 signaling (Dictyostelium discoideum)
      - MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
- Innate Immune System (Dictyostelium discoideum)
  - Toll-like Receptor Cascades (Dictyostelium discoideum)
    - Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
      - Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
      - Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
      - MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
      - MyD88-independent TLR4 cascade (Dictyostelium discoideum)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        phospho-p-IRAK2 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54LU8

Reference Genes

BioGPS Gene:8625597

dictyBase:DDB_G0286465

ENSEMBL:DDB_G0286465

KEGG:ddi:DDB_G0286465

Monarch:8625597

NCBI Gene:8625597

UCSC:Q54LU8

Reference Transcript

RefSeq:XM_632640.1

Participates

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

phospho-K63polyUb-hp-IRAK1 [cytosol]

phospho-p-IRAK2 [endosome membrane]

phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]

phospho-p-IRAK2 [plasma membrane]

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]

IRAK4 [cytosol]

Inferred From

p-IRAK2 [cytosol] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_637732.1

PRO

Q54LU8

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