Reactome | rgaA [cytosol]

rgaA [cytosol]

Stable Identifier

R-DDI-5626371-3

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

IQGAP1, Q54K32

Locations in the PathwayBrowser

Expand all

Signal Transduction (Dictyostelium discoideum)

- MAPK family signaling cascades (Dictyostelium discoideum)
  - MAPK1/MAPK3 signaling (Dictyostelium discoideum)
    - RAF/MAP kinase cascade (Dictyostelium discoideum)
      - MAP2K and MAPK activation (Dictyostelium discoideum)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
  - Signaling by Rho GTPases (Dictyostelium discoideum)
    - RHO GTPase Effectors (Dictyostelium discoideum)
      - RHO GTPases activate IQGAPs (Dictyostelium discoideum)
        
        GTP-bound RAC1 and CDC42 bind IQGAPs (Dictyostelium discoideum)
        
        IQGAP [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Dictyostelium discoideum)
        
        IQGAP [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 binds CLIP1 and microtubules (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAP1:CLIP1:microtubule [plasma membrane] (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAP1 [plasma membrane] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        IQGAPs bind F-actin, which is inhibited by calmodulin (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Dictyostelium discoideum)
        
        IQGAP [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAPs [plasma membrane] (Dictyostelium discoideum)
        
        IQGAP [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
    - RHO GTPase cycle (Dictyostelium discoideum)
      - RAC1 GTPase cycle (Dictyostelium discoideum)
        
        RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)
        
        RAC1 effectors [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Dictyostelium discoideum)
        
        RAC1 effectors [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
      - RAC2 GTPase cycle (Dictyostelium discoideum)
        
        RAC2 binds effectors at the plasma membrane (Dictyostelium discoideum)
        
        RAC2 plasma membrane effectors [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)
        
        RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Dictyostelium discoideum)
        
        RAC2 plasma membrane effectors [cytosol] (Dictyostelium discoideum)
        
        IQGAP1 dimer [cytosol] (Dictyostelium discoideum)
        
        Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)
        
        rgaA [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54K32

Gene Names

rgaA

Reference Genes

BioGPS Gene:8626227 rgaA

dictyBase:DDB_G0287585

ENSEMBL:DDB_G0287585

KEGG Gene (Dictyostelium discoideum):DDB_G0287585 rgaA

Monarch:8626227 rgaA

NCBI Gene:8626227 rgaA

Reference Transcript

RefSeq:XM_632040.1 rgaA

Participates

as a member of

Homologues of IQGAP1 [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

rgaA [plasma membrane]

rgaA [secretory granule membrane]

rgaA [cytosol]

Inferred From

IQGAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_637132.1

PRO

Q54K32

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34144	6	RAC1 [ficolin-1-rich granule membrane] (R-DDI-6804802) RAC1 [secretory granule membrane] (R-DDI-6804770) RAC1 [endoplasmic reticulum membrane] (R-DDI-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-DDI-2316446) RAC1 [cytosol] (R-DDI-442615) RAC1 [plasma membrane] (R-DDI-351141)	0.656	4

Cite Us!