Reactome | pirA [cytosol]

pirA [cytosol]

Stable Identifier

R-DDI-5672575

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

CYFIP1, Q6UK63

Locations in the PathwayBrowser

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Immune System (Dictyostelium discoideum)

- Innate Immune System (Dictyostelium discoideum)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
    - Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
      - Detachment of WASP/WAVE (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
      - p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Dictyostelium discoideum)
        
        p-Y,S,T-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Dictyostelium discoideum)
        
        p-Y-WRC [cytosol] (Dictyostelium discoideum)
        
        pirA [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q6UK63

Gene Names

pirA

Reference Genes

BioGPS Gene:8626322 pirA

dictyBase:DDB_G0287855

ENSEMBL:DDB_G0287855

KEGG:ddi:DDB_G0287855 pirA

Monarch:8626322 pirA

NCBI Gene:8626322 pirA

UCSC:Q6UK63 pirA

Reference Transcript

RefSeq:XM_631975.1 pirA

Participates

as a member of

RAC1 effectors [cytosol] (Dictyostelium discoideum)

as a candidate of

RHOG plasma membrane effectors [cytosol] (Dictyostelium discoideum)

as a component of

Other forms of this molecule

pirA [tertiary granule lumen]

pirA [secretory granule lumen]

pirA [extracellular region]

pirA [specific granule lumen]

pirA [cytosol]

Inferred From

CYFIP1,CYFIP2 [cytosol] (Homo sapiens)

CYFIP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_637067.1

PRO

Q6UK63

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