Reactome | phospho-drkD [cytosol]

phospho-drkD [cytosol]

Stable Identifier

R-DDI-5672664-2

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

p-S338,Y341,T491,S494,S621 RAF1, Q54TM7

Locations in the PathwayBrowser

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Signal Transduction (Dictyostelium discoideum)

- MAPK family signaling cascades (Dictyostelium discoideum)
  - MAPK1/MAPK3 signaling (Dictyostelium discoideum)
    - RAF/MAP kinase cascade (Dictyostelium discoideum)
      - MAP2K and MAPK activation (Dictyostelium discoideum)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Dictyostelium discoideum)
        
        activated RAF homo/heterodimer [cytosol] (Dictyostelium discoideum)
        
        activated RAF monomer [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Dictyostelium discoideum)
        
        activated RAF homo/heterodimer [cytosol] (Dictyostelium discoideum)
        
        activated RAF monomer [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
      - Negative regulation of MAPK pathway (Dictyostelium discoideum)
        
        PEBP1 binds activated RAF1 (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        PP2A dephosphorylates RAF1 (Dictyostelium discoideum)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        PP5 dephosphorylates RAF1 S338 (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
      - RAF activation (Dictyostelium discoideum)
        
        "Activator" RAF:YWHAB dimer binds RAS:GTP (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)
        
        phospho-drkD [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54TM7

Gene Names

drkD

Reference Genes

BioGPS Gene:8623174 drkD

dictyBase:DDB_G0281557

ENSEMBL:DDB_G0281557

KEGG Gene (Dictyostelium discoideum):DDB_G0281557 drkD

Monarch:8623174 drkD

NCBI Gene:8623174 drkD

Reference Transcript

RefSeq:XM_635472.1 drkD

Participates

as a member of

Homologues of p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

phospho-drkD [cytosol]

drkD [cytosol]

phospho-drkD [plasma membrane]

phospho-drkD [cytosol]

phospho-drkD [plasma membrane]

phospho-drkD [cytosol]

drkD [cytosol]

phospho-drkD [cytosol]

Inferred From

p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 621 (in Homo sapiens)

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 341 (in Homo sapiens)

Coordinate

341

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 338 (in Homo sapiens)

Coordinate

338

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 491 (in Homo sapiens)

Coordinate

491

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 494 (in Homo sapiens)

Coordinate

494

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_640564.1

IntEnz

2.7.11.1

PRO

Q54TM7

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