Reactome | GRB2-1:SOS1 [cytosol]

GRB2-1:SOS1 [cytosol]

Stable Identifier

R-DME-109797

Type

Complex

Species

Drosophila melanogaster

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - DAP12 interactions (Drosophila melanogaster)
    - DAP12 signaling (Drosophila melanogaster)
      - Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Release of p-PLCG1 (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
  - Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
    - FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
      - Autophosphorylation of BTK/ITK (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
    - FCERI mediated MAPK activation (Drosophila melanogaster)
      - Activation of RAC1 by VAV (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Autophosphorylation of PAK (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Phosphorylation and activation of VAV (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
      - PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
        
        p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
        
        GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

as an input of

as an output of

GRB2-1 binds SOS1 (Drosophila melanogaster)

Inferred From

GRB2-1:SOS1 [cytosol] (Homo sapiens)

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