In Drosophila there is a single insulin/IGF receptor homologue (DInr), seven insulin-like peptides (DILPs), and a single IRS homologue (Chico), in contrast to the insulin receptor, insulin and IRS entities, respectively, in mammals. DInr and the DILPs interact to regulate growth, haemolymph carbohydrate levels, reproduction and ageing.
© 2023 Reactome