Activated DTOR also phosphorylates D4EBP

Stable Identifier
R-DME-110518
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Activated DTOR also phosphorylates D4EBP
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DeIF4E is an initiation factor for eukaryotic translation. D4EBP forms a complex with DeIF4E, inactivating the latter. Activated DTOR phosphorylates D4EBP on a threonine residue, causing it to dissociate from DeIF4E.
Literature References
PubMed ID Title Journal Year
11389445 The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila.

Birnbaum, MJ, Lasko, PF, Verdú, J, Lachance, PE, Miron, M, Sonenberg, N

Nat Cell Biol 2001
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of signal transduction (0009967)
Catalyst Activity

protein serine/threonine kinase activity of Activated DTOR [cytosol]

Physical Entity
Activated DTOR [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Jassal, B  (2004-02-11)
Created
Jassal, B  (2004-02-11)
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