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Cbl [cytosol]
Stable Identifier
R-DME-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
CBL, Q9VSK2
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Drosophila melanogaster)
Regulation of signaling by CBL (Drosophila melanogaster)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
Binding of CBL to EGFR (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL binds and ubiquitinates phosphorylated Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL ubiquitinates Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Localization of CBL:GRB2 to the membrane (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:CBL) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Sprouty lures CBL away from EGFR (Drosophila melanogaster)
CBL:SPRY1/2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR2 (Drosophila melanogaster)
Negative regulation of FGFR2 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR3 (Drosophila melanogaster)
Negative regulation of FGFR3 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR4 (Drosophila melanogaster)
Negative regulation of FGFR4 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by SCF-KIT (Drosophila melanogaster)
Regulation of KIT signaling (Drosophila melanogaster)
Recruitment of CBL to KIT (Drosophila melanogaster)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
CBL binds TGFBR2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
TGFBR2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL neddylates TGFBR2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
TGFBR2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VSK2
Gene Names
Cbl
Reference Genes
BioGPS Gene:38961 Cbl
ENSEMBL:FBgn0020224
FlyBase:FBgn0020224
KEGG:dme:Dmel_CG7037 Cbl
Monarch:38961 Cbl
NCBI Gene:38961 Cbl
UCSC:Q9VSK2 Cbl
Reference Transcript
RefSeq:NM_139967.2 Cbl
Other Identifiers
143910_at
148403_at
1626708_at
1635580_at
38961
GO:0001754
GO:0001784
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005737
GO:0005886
GO:0005938
GO:0006109
GO:0006511
GO:0006513
GO:0007163
GO:0007165
GO:0007166
GO:0007175
GO:0007465
GO:0007476
GO:0008069
GO:0008270
GO:0009950
GO:0009953
GO:0016567
GO:0016740
GO:0017124
GO:0022414
GO:0023051
GO:0030154
GO:0030971
GO:0032353
GO:0042059
GO:0042127
GO:0043065
GO:0045121
GO:0045746
GO:0046872
GO:0047690
GO:0048134
GO:0048260
GO:0060255
GO:0061630
GO:0070373
GO:0140096
GO:1903688
Participates
as an input of
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)
Sprouty lures CBL away from EGFR (Drosophila melanogaster)
Binding of CBL to EGFR (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
Recruitment of CBL to KIT (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
CBL binds TGFBR2 (Drosophila melanogaster)
as a component of
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
CBL:SPRY1/2 [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
TGFBR2:CBL [plasma membrane] (Drosophila melanogaster)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
CBL neddylates TGFBR2 (Drosophila melanogaster)
Other forms of this molecule
phospho-Cbl [plasma membrane]
phospho-Cbl [cytosol]
phospho-Cbl [cytosol]
phospho-Cbl [cytosol]
Cbl [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_648224.1
ENSEMBL
FBtr0076615
,
FBpp0076342
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