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phospho-cact [cytosol]
Stable Identifier
R-DME-1168581
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Ub-K21,22-p-S32,S36-NFKBIA, Q03017
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
Activation of NF-kappaB in B cells (Drosophila melanogaster)
Ubiquitinated IkB is degraded (Drosophila melanogaster)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Drosophila melanogaster)
NF-KappaB p50:p50:ub-p-IKBA [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Drosophila melanogaster)
ub-p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Drosophila melanogaster)
ub-p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
phospho-cact [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q03017 cact
Gene Names
cact, CG5848
Chain
chain:1-500
Reference Genes
BioGPS Gene:34969 cact
CTD Gene:34969 cact
KEGG:dme:Dmel_CG5848 cact
Monarch:34969 cact
NCBI Gene:34969 cact
UCSC:Q03017 cact
Reference Transcript
RefSeq:NM_057595.4 cact
RefSeq:NM_057594.4 cact
RefSeq:NM_001273567.1 cact
RefSeq:NM_165152.2 cact
RefSeq:NM_205999.2 cact
Other Identifiers
153684_at
1629899_at
1636926_s_at
34969
GO:0002376
GO:0002789
GO:0005515
GO:0005737
GO:0005829
GO:0006355
GO:0007253
GO:0007399
GO:0009950
GO:0009953
GO:0019730
GO:0022414
GO:0031594
GO:0043124
GO:0043226
GO:0045611
GO:0045751
GO:0046843
GO:0048477
GO:0048856
GO:0051059
GO:0051220
GO:0071212
GO:0071356
GO:0098542
GO:0140311
GO:0140313
Participates
as a component of
NF-KappaB p50:p50:ub-p-IKBA [cytosol] (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
as a member of
ub-p-IKB alpha,beta,epsilon [cytosol] (Drosophila melanogaster)
Other forms of this molecule
CACT [cytosol]
Phospho CACT [cytosol]
cact [nucleoplasm]
phospho-cact [cytosol]
cact [cytosol]
Inferred From
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 32 (in Homo sapiens)
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36 (in Homo sapiens)
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 21 (in Homo sapiens)
Coordinate
21
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 22 (in Homo sapiens)
Coordinate
22
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001260496.1
,
NP_476943.1
,
NP_476942.1
,
NP_995721.1
,
NP_723960.1
ENSEMBL
FBpp0080402
,
FBpp0080403
,
FBpp0089296
,
FBpp0308004
,
FBtr0080847
,
FBtr0337081
,
FBtr0080844
,
FBtr0080845
FlyBase
FBgn0000250
PRO
Q03017
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15330 dl
14
dl [nucleoplasm]
(R-DME-177676)
dl [cytosol]
(R-DME-168172)
dl [cytosol]
(R-DME-5607652)
dl [nucleoplasm]
(R-DME-5607656)
phospho-dl [nucleoplasm]
(R-DME-5624468)
phospho-dl [nucleoplasm]
(R-DME-5660642)
dl [cytosol]
(R-DME-1168579)
dl [nucleoplasm]
(R-DME-1168585)
dl [nucleoplasm]
(R-DME-4755466)
phospho-dl [nucleoplasm]
(R-DME-9861499)
dl [nucleoplasm]
(R-DME-8865233)
Phospho DL [nucleoplasm]
(R-DME-214731)
Phospho DL [cytosol]
(R-DME-214732)
DL [cytosol]
(R-DME-206011)
0.745
7
UniProt:Q9VR99
1
cactin [nucleoplasm]
(R-DME-9769591)
0.581
5
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-p-Y187,Y198-CHUK [cytosol]
(R-DME-9861501)
phospho-p-T23-CHUK [cytosol]
(R-DME-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-DME-177667)
phospho-p-S177,S181-IKBKB [cytosol]
(R-DME-202506)
CHUK [cytosol]
(R-DME-168104)
IKBKB [cytosol]
(R-DME-168114)
0.544
2
UniProt:Q9V393 krz
10
krz [cytoplasmic vesicle membrane]
(R-DME-351187-3)
krz [Golgi membrane]
(R-DME-350831-3)
krz [lysosomal membrane]
(R-DME-432701-3)
krz [endocytic vesicle membrane]
(R-DME-9910881)
krz [endocytic vesicle membrane]
(R-DME-9910882-3)
krz [cytosol]
(R-DME-6783000)
krz [cytosol]
(R-DME-6783186-3)
Krz [cytosol]
(R-DME-2071841)
krz [cytosol]
(R-DME-416464)
krz [cytosol]
(R-DME-264470-3)
0.544
2
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