Reactome | Hexo2 [lysosomal lumen]

Hexo2 [lysosomal lumen]

Stable Identifier

R-DME-1605799-3

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

lysosomal lumen

Synonyms

HEXA(88-528), Q9W3C4

Locations in the PathwayBrowser

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Metabolism (Drosophila melanogaster)

- Metabolism of carbohydrates (Drosophila melanogaster)
  - Glycosaminoglycan metabolism (Drosophila melanogaster)
    - Chondroitin sulfate/dermatan sulfate metabolism (Drosophila melanogaster)
      - CS/DS degradation (Drosophila melanogaster)
        
        HEXA cleaves the terminal GalNAc from DS (Drosophila melanogaster)
        
        bHEXA [lysosomal lumen] (Drosophila melanogaster)
        
        HEXA dimer [lysosomal lumen] (Drosophila melanogaster)
        
        Mature HEXA [lysosomal lumen] (Drosophila melanogaster)
        
        Homologues of HEXA(88-528) [lysosomal lumen] (Drosophila melanogaster)
        
        Hexo2 [lysosomal lumen] (Drosophila melanogaster)
    - Hyaluronan metabolism (Drosophila melanogaster)
      - Hyaluronan uptake and degradation (Drosophila melanogaster)
        
        HEXA cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)
        
        bHEXA [lysosomal lumen] (Drosophila melanogaster)
        
        HEXA dimer [lysosomal lumen] (Drosophila melanogaster)
        
        Mature HEXA [lysosomal lumen] (Drosophila melanogaster)
        
        Homologues of HEXA(88-528) [lysosomal lumen] (Drosophila melanogaster)
        
        Hexo2 [lysosomal lumen] (Drosophila melanogaster)
    - Keratan sulfate/keratin metabolism (Drosophila melanogaster)
      - Keratan sulfate degradation (Drosophila melanogaster)
        
        HEXA cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)
        
        bHEXA [lysosomal lumen] (Drosophila melanogaster)
        
        HEXA dimer [lysosomal lumen] (Drosophila melanogaster)
        
        Mature HEXA [lysosomal lumen] (Drosophila melanogaster)
        
        Homologues of HEXA(88-528) [lysosomal lumen] (Drosophila melanogaster)
        
        Hexo2 [lysosomal lumen] (Drosophila melanogaster)
- Metabolism of lipids (Drosophila melanogaster)
  - Sphingolipid metabolism (Drosophila melanogaster)
    - Glycosphingolipid metabolism (Drosophila melanogaster)
      - Glycosphingolipid catabolism (Drosophila melanogaster)
        
        bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Drosophila melanogaster)
        
        bHEXA,bHEXB [lysosomal lumen] (Drosophila melanogaster)
        
        bHEXA [lysosomal lumen] (Drosophila melanogaster)
        
        HEXA dimer [lysosomal lumen] (Drosophila melanogaster)
        
        Mature HEXA [lysosomal lumen] (Drosophila melanogaster)
        
        Homologues of HEXA(88-528) [lysosomal lumen] (Drosophila melanogaster)
        
        Hexo2 [lysosomal lumen] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W3C4

Gene Names

Hexo2

Reference Genes

BioGPS Gene:31808 Hexo2

ENSEMBL:FBgn0041629

Flybase:FBgn0041629

KEGG Gene (Drosophila melanogaster):Dmel_CG1787 Hexo2

Monarch:31808 Hexo2

NCBI Gene:31808 Hexo2

UCSC:Q9W3C4 Hexo2

Reference Transcript

RefSeq:NM_080342.4 Hexo2

Other Identifiers

144712_at

1640957_at

31808

GO:0003824

GO:0004553

GO:0004563

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005886

GO:0005975

GO:0006517

GO:0006629

GO:0006689

GO:0008152

GO:0016020

GO:0016231

GO:0016787

GO:0016798

GO:0019953

GO:0030203

GO:0036211

GO:0043226

GO:0102148

GO:1901135

Participates

as a member of

Homologues of HEXA(88-528) [lysosomal lumen] (Drosophila melanogaster)

Other forms of this molecule

Hexo2 [extracellular region]

Hexo2 [azurophil granule lumen]

Hexo2 [lysosomal lumen]

Inferred From

HEXA(88-528) [lysosomal lumen] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via L-cystine (cross-link) at 104 and 58 (in Homo sapiens)

Coordinate

104

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_525081.1

Flybase

FBgn0041629