Chico is phosphorylated

Stable Identifier
R-DME-164696
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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The beta subunit of the DINR complex binds and phosphorylates Chico. Chico has 3 phosphotyrosine binding domains on residues 411, 911 and 948 where it can be phosphorylated. The tyrosine kinase function of DINR phosphorylates Chico on these domains. Phosphorylated Chico binds to SH2 domain-containing proteins such as PI3K (Phosphoinositide 3-Kinase).

Literature References
PubMed ID Title Journal Year
10455177 The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survival.

Garofalo, RS, Marin-Hincapie, M

J Biol Chem 1999
10801879 Characterization of Drosophila insulin receptor substrate.

Taylor, SI, Haft, CR, Xu, P, Poltilove, RM, Jacobs, AR

J Biol Chem 2000
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Chico:Activated DINR:DILP complex [plasma membrane]

Authored
Created
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