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IKKbeta [cytosol]
Stable Identifier
R-DME-168104
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
CHUK, Q9VEZ5
Locations in the PathwayBrowser for interactor UniProt:Q9VEZ5 IKKbeta
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
AKT phosphorylates targets in the cytosol (Drosophila melanogaster)
AKT phosphorylates IKKalpha (Drosophila melanogaster)
IKKbeta [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VEZ5 IKKbeta
Gene Names
IKKbeta, DIK, ird5, CG4201
Chain
chain:1-751
Reference Genes
BioGPS Gene:44432 IKKbeta
KEGG:dme:Dmel_CG4201 IKKbeta
Monarch:44432 IKKbeta
NCBI Gene:44432 IKKbeta
UCSC:Q9VEZ5 IKKbeta
Reference Transcript
RefSeq:NM_080012.4 IKKbeta
Other Identifiers
142654_at
1625974_at
44432
GO:0000166
GO:0002230
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006355
GO:0006468
GO:0006963
GO:0008384
GO:0008385
GO:0016301
GO:0016740
GO:0019731
GO:0030163
GO:0033209
GO:0042802
GO:0043123
GO:0045087
GO:0045088
GO:0045944
GO:0051607
GO:0061057
GO:0071456
GO:0098542
GO:0140096
GO:0140896
Participates
as a component of
FKBP5:CHUK [cytosol] (Drosophila melanogaster)
IKKA dimer [cytosol] (Drosophila melanogaster)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Drosophila melanogaster)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
CHUK:IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
as an input of
AKT phosphorylates IKKalpha (Drosophila melanogaster)
CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)
Other forms of this molecule
IRD5 [cytosol]
Phospho IRD5 [cytosol]
phospho-IKKbeta [cytosol]
phospho-IKKbeta [cytosol]
phospho-IKKbeta [cytosol]
phospho-IKKbeta [cytosol]
IKKbeta [cytosol]
Inferred From
CHUK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524751.3
ENSEMBL
FBgn0024222
,
FBpp0293344
,
FBtr0304804
FlyBase
FBgn0024222
PRO
Q9VEZ5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GYV5 key
10
KEY [cytosol]
(R-DME-206178)
key [recycling endosome membrane]
(R-DME-8854141)
key [nucleoplasm]
(R-DME-4755413)
phospho-key [nucleoplasm]
(R-DME-2562595)
phospho-key [cytosol]
(R-DME-2562525)
key [Golgi membrane]
(R-DME-2161111)
key [cytosol]
(R-DME-202530)
key [cytosol]
(R-DME-168108)
key [cytosol]
(R-DME-9687907)
phospho-key [cytosol]
(R-DME-9687840)
0.632
4
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-IKKbeta [cytosol]
(R-DME-9861501)
phospho-IKKbeta [cytosol]
(R-DME-198615)
phospho-IKKbeta [cytosol]
(R-DME-177667)
phospho-IKKbeta [cytosol]
(R-DME-202506)
IKKbeta [cytosol]
(R-DME-168104)
IKKbeta [cytosol]
(R-DME-168114)
0.623
2
UniProt:Q03017 cact
6
CACT [cytosol]
(R-DME-205871)
Phospho CACT [cytosol]
(R-DME-205886)
cact [nucleoplasm]
(R-DME-4656929)
phospho-cact [cytosol]
(R-DME-1168581)
phospho-cact [cytosol]
(R-DME-177677)
cact [cytosol]
(R-DME-168151)
0.544
2
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