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MAPK8 [cytosol]
Stable Identifier
R-DME-168141
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P92208
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
Oxidative Stress Induced Senescence (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-38 signaling (Drosophila melanogaster)
MAPK8 phosphorylation (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Drosophila melanogaster)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
Cell death signalling via NRAGE, NRIF and NADE (Drosophila melanogaster)
NRAGE signals death through JNK (Drosophila melanogaster)
GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)
MAPK8 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P92208 bsk
Gene Names
bsk, JNK, CG5680
Chain
chain:1-372
Reference Genes
BioGPS Gene:44801 bsk
CTD Gene:44801 bsk
KEGG Gene (Drosophila melanogaster):Dmel_CG5680 bsk
Monarch:44801 bsk
NCBI Gene:44801 bsk
Reference Transcript
RefSeq:NM_164900.3 bsk
RefSeq:NM_001169461.3 bsk
RefSeq:NM_001169459.1 bsk
Other Identifiers
153395_at
1625533_at
1626404_a_at
1634580_at
44801
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0006914
GO:0006979
GO:0007254
GO:0007258
GO:0007391
GO:0007395
GO:0007411
GO:0007616
GO:0008284
GO:0009408
GO:0009605
GO:0010508
GO:0010628
GO:0010942
GO:0012501
GO:0016192
GO:0016301
GO:0016310
GO:0016319
GO:0016740
GO:0019731
GO:0022414
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0030707
GO:0033209
GO:0033554
GO:0034599
GO:0034614
GO:0035006
GO:0035313
GO:0035556
GO:0036211
GO:0042060
GO:0043068
GO:0043226
GO:0043652
GO:0046529
GO:0046843
GO:0046844
GO:0048010
GO:0048615
GO:0048666
GO:0048674
GO:0048675
GO:0048803
GO:0048812
GO:0048856
GO:0048870
GO:0050877
GO:0061024
GO:0061057
GO:0071243
GO:0071276
GO:0071907
GO:0098542
GO:0106310
GO:0140096
GO:0140255
GO:1903688
GO:1904801
Participates
as an input of
GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)
MAPK8 phosphorylation (Drosophila melanogaster)
as a member of
MAPK8,9,10 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
BSK [cytosol]
Phospho BSK [nucleoplasm]
Phospho BSK [cytosol]
MAPK10 [cytosol]
MAPK9 [cytosol]
phospho-p-T183,Y185-MAPK9 [cytosol]
phospho-p-T,Y-MAPK8 [cytosol]
phospho-p-T221,Y223-MAPK10 [cytosol]
phospho-p-T,Y-MAPK8 [nucleoplasm]
phospho-p-T183,Y185-MAPK9 [nucleoplasm]
phospho-p-T221,Y223-MAPK10 [nucleoplasm]
Inferred From
MAPK8 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001162932.1
,
NP_001162930.1
,
NP_723541.1
Flybase
FBgn0000229
IntEnz
2.7.11.24
PRO
P92208
PDB
5AWM
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VNR6 Q9VNR6
0.553
2
UniProt:Q9U1K1 SPIR
0.502
2
UniProt:O61444
2
phospho-p-S257,T261-MAP2K4 [cytosol]
(R-DME-168170)
MAP2K4 [cytosol]
(R-DME-168107)
0.502
2
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