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EIF2AK2 [cytosol]
Stable Identifier
R-DME-168699
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q9NIV1
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
ISG15 antiviral mechanism (Drosophila melanogaster)
ISGylation of host proteins (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
ISGylated host proteins [cytosol] (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
ISGylated host proteins [cytosol] (Drosophila melanogaster)
ISG15 targets [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
PKR-mediated signaling (Drosophila melanogaster)
DNAJC3 binds PKR (Drosophila melanogaster)
DNAJC3:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
DUS2 binds PKR (Drosophila melanogaster)
DUS2:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
Heparin binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 dimer:heparin [cytosol] (Drosophila melanogaster)
EIF2AK2 dimer [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
IKK complex is activated by PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
ILF3 binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
ILF3:EIF2AK2 dimer [cytosol] (Drosophila melanogaster)
EIF2AK2 dimer [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
ISGylation of PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
NCK1 binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2:NCK1 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
NPM binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
NPM1:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
PKR binds activating host RNA (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 dimer:Host RNA activators [cytosol] (Drosophila melanogaster)
EIF2AK2 dimer [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
PKR inhibitors bind PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2:PKR inhibitors [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
SPHK1 binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2:p-SPHK1 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
STAT1,STAT3 binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
STAT1,STAT3:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
p-PRKRA dimer binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
p-TARBP2 binds PKR (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
p-TARBP2:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9NIV1
Reference Genes
BioGPS Gene:40653
ENSEMBL:FBgn0037327
FlyBase:FBgn0037327
KEGG Gene (Drosophila melanogaster):Dmel_CG2087
Monarch:40653
NCBI Gene:40653
Reference Transcript
RefSeq:NM_141281.3
Other Identifiers
149333_at
1641072_at
40653
GO:0000166
GO:0000278
GO:0003824
GO:0004672
GO:0004674
GO:0004686
GO:0004694
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006417
GO:0006468
GO:0006914
GO:0006986
GO:0010389
GO:0010508
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0034976
GO:0036211
GO:0036499
GO:0043226
GO:0045182
GO:0046330
GO:0070887
GO:0106310
GO:0140096
Participates
as a member of
ISG15 targets [cytosol] (Drosophila melanogaster)
as an input of
DUS2 binds PKR (Drosophila melanogaster)
SPHK1 binds PKR (Drosophila melanogaster)
DNAJC3 binds PKR (Drosophila melanogaster)
Heparin binds PKR (Drosophila melanogaster)
PKR binds activating host RNA (Drosophila melanogaster)
STAT1,STAT3 binds PKR (Drosophila melanogaster)
NCK1 binds PKR (Drosophila melanogaster)
ISGylation of PKR (Drosophila melanogaster)
ILF3 binds PKR (Drosophila melanogaster)
NPM binds PKR (Drosophila melanogaster)
p-PRKRA dimer binds PKR (Drosophila melanogaster)
PKR inhibitors bind PKR (Drosophila melanogaster)
p-TARBP2 binds PKR (Drosophila melanogaster)
IKK complex is activated by PKR (Drosophila melanogaster)
as a component of
p-TARBP2:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2:PKR inhibitors [cytosol] (Drosophila melanogaster)
DNAJC3:EIF2AK2 [cytosol] (Drosophila melanogaster)
DUS2:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2:NCK1 [cytosol] (Drosophila melanogaster)
EIF2AK2:p-SPHK1 [cytosol] (Drosophila melanogaster)
STAT1,STAT3:EIF2AK2 [cytosol] (Drosophila melanogaster)
NPM1:EIF2AK2 [cytosol] (Drosophila melanogaster)
EIF2AK2 dimer [cytosol] (Drosophila melanogaster)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
Other forms of this molecule
EIF2AK3 [endoplasmic reticulum membrane]
phospho-p-EIF2AK2 [nucleoplasm]
SUMO-EIF2AK2 [cytosol]
ISG15-EIF2AK2 [cytosol]
phospho-p-EIF2AK2 [cytosol]
Inferred From
EIF2AK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_649538.1
Flybase
FBgn0037327
PRO
Q9NIV1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18431-3 SGG
0.597
3
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