Reactome | TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]

TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]

Stable Identifier

R-DME-170841

Type

Complex

Species

Drosophila melanogaster

Compartment

plasma membrane

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
TGFBR2 homodimer [plasma membrane] (Drosophila melanogaster)

Participates

as a component of

Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Drosophila melanogaster)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Drosophila melanogaster)

as an input of

I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Drosophila melanogaster)

as an output of

TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)

Inferred From

TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)