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Dimeric TGFB1 [extracellular region]
Stable Identifier
R-DME-170852
Type
Complex
Species
Drosophila melanogaster
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
RUNX3 regulates CDKN1A transcription (Drosophila melanogaster)
RUNX3 binds ZFHX3 (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
RUNX3 regulates p14-ARF (Drosophila melanogaster)
EP300 acetylates RUNX3 (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Regulation of RUNX3 expression and activity (Drosophila melanogaster)
RUNX3 translocates to the nucleus (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Dimeric TGF-beta-1 binds to the receptor (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
Degradation of TGF-beta receptor complex (Drosophila melanogaster)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Drosophila melanogaster)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)
TGFB1:LAP1 [extracellular region] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFBR2 recruits TGFBR1 (Drosophila melanogaster)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Drosophila melanogaster)
Disassembly of tight junctions (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
SMURF1 ubiquitinates RHOA (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Drosophila melanogaster)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dimeric TGFB1 [extracellular region] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Homologues of TGFB1 [extracellular region]
(Drosophila melanogaster)
Participates
as a component of
TGFB1:LAP1 [extracellular region] (Drosophila melanogaster)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Drosophila melanogaster)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Drosophila melanogaster)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Drosophila melanogaster)
as an input of
Dimeric TGF-beta-1 binds to the receptor (Drosophila melanogaster)
This entity regulates
Positively
EP300 acetylates RUNX3
(Drosophila melanogaster)
RUNX3 binds ZFHX3
(Drosophila melanogaster)
RUNX3 translocates to the nucleus
(Drosophila melanogaster)
Inferred From
Dimeric TGFB1 [extracellular region]
(Homo sapiens)
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