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Dad [cytosol]
Stable Identifier
R-DME-173478
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
SMAD7, A0A6H2EEY2
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Drosophila melanogaster)
SMAD7:SMURF2 [cytosol] (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Drosophila melanogaster)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Drosophila melanogaster)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
Degradation of TGF-beta receptor complex (Drosophila melanogaster)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Drosophila melanogaster)
Dad [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:A0A6H2EEY2
Gene Names
Dad
Reference Genes
ENSEMBL:FBgn0020493
FlyBase:FBgn0020493
Other Identifiers
152910_at
1633556_s_at
42059
GO:0003677
GO:0005515
GO:0005634
GO:0005667
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007179
GO:0007443
GO:0007448
GO:0007476
GO:0007488
GO:0009653
GO:0009791
GO:0016335
GO:0016477
GO:0023052
GO:0030154
GO:0030509
GO:0030718
GO:0031290
GO:0034330
GO:0035214
GO:0043226
GO:0045886
GO:0046872
GO:0048635
GO:0048856
GO:0048870
GO:0050793
GO:0051239
GO:0060395
GO:0070411
GO:0071144
GO:0090254
GO:0098772
GO:0140416
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Drosophila melanogaster)
SMAD7:SMURF2 [cytosol] (Drosophila melanogaster)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Drosophila melanogaster)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Drosophila melanogaster)
as an input of
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)
Other forms of this molecule
Dad [cytosol]
Dad [nucleoplasm]
Inferred From
SMAD7 [cytosol]
(Homo sapiens)
Cross References
Flybase
FBgn0020493
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8I7C3-2 LASP
0.488
2
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