Reactome | Smurf [cytosol]

Smurf [cytosol]

Stable Identifier

R-DME-173537

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

SMURF2, Q9V853

Locations in the PathwayBrowser

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Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Deubiquitination (Drosophila melanogaster)
    - Ub-specific processing proteases (Drosophila melanogaster)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
        
        USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
        
        SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
        
        SMAD7:SMURF2:TGFBR1 [plasma membrane] (Drosophila melanogaster)
        
        SMAD7:SMURF2 [cytosol] (Drosophila melanogaster)
        
        Smurf [cytosol] (Drosophila melanogaster)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Drosophila melanogaster)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Drosophila melanogaster)
        
        SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Drosophila melanogaster)
        
        Smurf [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V853

Gene Names

Smurf

Reference Genes

BioGPS Gene:36999 Smurf

CTD Gene:36999 Smurf

ENSEMBL:FBgn0029006

Flybase:FBgn0029006

KEGG Gene (Drosophila melanogaster):Dmel_CG4943 Smurf

Monarch:36999 Smurf

NCBI Gene:36999 Smurf

Reference Transcript

Other Identifiers

147382_at

1632355_at

36999

GO:0000151

GO:0000209

GO:0001700

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0007293

GO:0009966

GO:0016192

GO:0016567

GO:0016740

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030514

GO:0030579

GO:0035331

GO:0036211

GO:0040008

GO:0043161

GO:0045879

GO:0045880

GO:0048232

GO:0048260

GO:0048619

GO:0048856

GO:0061630

GO:0140096

Participates

as a component of

as an output of

as an input of

as a member of

E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Smurf [cytosol]

Smurf [nucleoplasm]

Inferred From

SMURF [cytosol] (Homo sapiens)

SMURF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001261061.1, NP_523779.1

Flybase

FBgn0029006

PRO

Q9V853

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42003	10	Ub-SMAD1 [cytosol] (R-DME-6782768) SMAD1 [cytosol] (R-DME-201468) SMAD9 [cytosol] (R-DME-201478) SMAD5 [cytosol] (R-DME-201431) phospho-p-S463,S465-SMAD5 [nucleoplasm] (R-DME-201432) phospho-p-S465,S467-SMAD9 [nucleoplasm] (R-DME-201474) phospho-p-S463,S465-SMAD1 [cytosol] (R-DME-201464) phospho-p-S465,S467-SMAD9 [cytosol] (R-DME-201441) phospho-p-S463,S465-SMAD5 [cytosol] (R-DME-201473) phospho-p-S463,S465-SMAD1 [nucleoplasm] (R-DME-201483)	0.502	2
UniProt:P23647 fu	2	Phospho FU [cytosol] (R-DME-205779) FU [cytosol] (R-DME-205872)	0.499	5