Reactome | shtd [cytosol]

shtd [cytosol]

Stable Identifier

R-DME-174189

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

ANAPC1, Q9VXV3

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - Mitotic Spindle Checkpoint (Drosophila melanogaster)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Drosophila melanogaster)
        
        Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - M Phase (Drosophila melanogaster)
    - Mitotic Metaphase and Anaphase (Drosophila melanogaster)
      - Mitotic Anaphase (Drosophila melanogaster)
        
        Separation of Sister Chromatids (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Securin (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        APC/C:Cdc20 mediated degradation of Securin (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Securin (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
        
        APC-Cdc20 mediated degradation of Nek2A (Drosophila melanogaster)
        
        Association of Nek2A with MCC:APC/C (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Multiubiquitination of Nek2A (Drosophila melanogaster)
        
        Multiubiquitinated Nek2A [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Nek2A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
        
        Association of Cyclin A with the APC/C (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Drosophila melanogaster)
        
        Association of Cdh1 with the APC/C (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        Dissociation of Cdc20 from APC/C complex (Drosophila melanogaster)
        
        CDC20:p-APC/C [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
      - Regulation of APC/C activators between G1/S and early anaphase (Drosophila melanogaster)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Drosophila melanogaster)
        
        Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
        
        MCC:APC/C complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Synthesis of DNA (Drosophila melanogaster)
      - Switching of origins to a post-replicative state (Drosophila melanogaster)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Drosophila melanogaster)
        
        shtd [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VXV3

Gene Names

shtd

Reference Genes

BioGPS Gene:32473 shtd

ENSEMBL:FBgn0004391

Flybase:FBgn0004391

KEGG Gene (Drosophila melanogaster):Dmel_CG9198 shtd

Monarch:32473 shtd

NCBI Gene:32473 shtd

UCSC:Q9VXV3 shtd

Reference Transcript

RefSeq:NM_132797.3 shtd

Other Identifiers

154789_at

1632043_a_at

32473

GO:0000278

GO:0005634

GO:0005680

GO:0007059

GO:0007091

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0048749

GO:0048856

GO:0060090

GO:0070979

GO:0140014

Participates

as a component of

Other forms of this molecule

shtd [nucleoplasm]

Inferred From

ANAPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_573025.2

Flybase

FBgn0004391

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18824 arm	20	arm [nucleoplasm] (R-DME-3451168) arm [cytosol] (R-DME-448839) phospho-arm [cytosol] (R-DME-8942374) phospho-arm [cytosol] (R-DME-8942369) phospho-arm [cytosol] (R-DME-8942367) phospho-arm [cytosol] (R-DME-8942363) arm [plasma membrane] (R-DME-9038440) arm [plasma membrane] (R-DME-437260) arm [cytosol] (R-DME-202930) arm [cytosol] (R-DME-202950) phospho-arm [cytosol] (R-DME-3134933) phospho-arm [nucleoplasm] (R-DME-3134926) arm [ficolin-1-rich granule lumen] (R-DME-6801028) arm [extracellular region] (R-DME-6806309) arm [specific granule lumen] (R-DME-6799534) arm [cytosol] (R-DME-201598) Phospho (4 sites) ARM [cytosol] (R-DME-205960) ARM [cytosol] (R-DME-205774) Phospho ARM [cytosol] (R-DME-206159) ARM [nucleoplasm] (R-DME-205878)	0.462	2
UniProt:Q9VH81	2	PpD3 [nucleoplasm] (R-DME-5683410) PpD3 [cytosol] (R-DME-5675402)	0.462	2
UniProt:P07207 N	20	N [extracellular region] (R-DME-2299700) N [extracellular region] (R-DME-8855833) N [extracellular region] (R-DME-8855834) N [extracellular region] (R-DME-8855850) N [extracellular region] (R-DME-8855840) N [extracellular region] (R-DME-8855829) N [extracellular region] (R-DME-8855863) N [extracellular region] (R-DME-3791190) N [extracellular region] (R-DME-3791188) N [extracellular region] (R-DME-3791186) N [extracellular region] (R-DME-3791182) N [extracellular region] (R-DME-3791181) N [extracellular region] (R-DME-3791193) N [extracellular region] (R-DME-3791191) N [extracellular region] (R-DME-3791189) N [extracellular region] (R-DME-3791184) N [extracellular region] (R-DME-3791180) N [extracellular region] (R-DME-3791179) N [extracellular region] (R-DME-3791192) N [extracellular region] (R-DME-3791174)	0.462	2

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