Reactome | shtd [nucleoplasm]

shtd [nucleoplasm]

Stable Identifier

R-DME-174217

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

ANAPC1, Q9VXV3

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular Senescence (Drosophila melanogaster)
    - Senescence-Associated Secretory Phenotype (SASP) (Drosophila melanogaster)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Drosophila melanogaster)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Drosophila melanogaster)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)
        
        shtd [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VXV3

Gene Names

shtd

Reference Genes

BioGPS Gene:32473 shtd

ENSEMBL:FBgn0004391

Flybase:FBgn0004391

KEGG Gene (Drosophila melanogaster):Dmel_CG9198 shtd

Monarch:32473 shtd

NCBI Gene:32473 shtd

UCSC:Q9VXV3 shtd

Reference Transcript

RefSeq:NM_132797.3 shtd

Other Identifiers

154789_at

1632043_a_at

32473

GO:0000278

GO:0005634

GO:0005680

GO:0007059

GO:0007091

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0048749

GO:0048856

GO:0060090

GO:0070979

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

shtd [cytosol]

Inferred From

ANAPC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_573025.2

Flybase

FBgn0004391

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9VH81	2	PpD3 [nucleoplasm] (R-DME-5683410) PpD3 [cytosol] (R-DME-5675402)	0.462	2
UniProt:P18824 arm	20	arm [nucleoplasm] (R-DME-3451168) arm [cytosol] (R-DME-448839) arm [cytosol] (R-DME-202930) arm [cytosol] (R-DME-202950) phospho-arm [cytosol] (R-DME-8942374) phospho-arm [cytosol] (R-DME-8942369) phospho-arm [cytosol] (R-DME-8942367) phospho-arm [cytosol] (R-DME-8942363) arm [plasma membrane] (R-DME-9038440) arm [plasma membrane] (R-DME-437260) arm [ficolin-1-rich granule lumen] (R-DME-6801028) arm [extracellular region] (R-DME-6806309) arm [specific granule lumen] (R-DME-6799534) phospho-arm [cytosol] (R-DME-3134933) phospho-arm [nucleoplasm] (R-DME-3134926) arm [cytosol] (R-DME-201598) Phospho (4 sites) ARM [cytosol] (R-DME-205960) ARM [cytosol] (R-DME-205774) Phospho ARM [cytosol] (R-DME-206159) ARM [nucleoplasm] (R-DME-205878)	0.462	2
UniProt:P07207 N	7	Elongated Fucose N [plasma membrane] (R-DME-206245) Fucose N [plasma membrane] (R-DME-205885) Notch NICD fragment [cytosol] (R-DME-177092) Notch NICD fragment [nucleoplasm] (R-DME-177090) Glc,Fuc-N [endoplasmic reticulum lumen] (R-DME-2032242) Glc,Fuc-N [Golgi lumen] (R-DME-2032747) Glc,Fuc-N [plasma membrane] (R-DME-2071837)	0.462	2

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