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Cul1 [cytosol]
Stable Identifier
R-DME-174230
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
CUL1, Q24311
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Drosophila melanogaster)
Formation of the SCF-FBXL7 complex (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)
SCF-FBXL7:AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF:FBXL7 binds AURKA (Drosophila melanogaster)
SCF-FBXL7:AURKA [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Regulation of APC/C activators between G1/S and early anaphase (Drosophila melanogaster)
SCF-beta-TrCP mediated degradation of Emi1 (Drosophila melanogaster)
Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Drosophila melanogaster)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Drosophila melanogaster)
BTRC:CUL1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Drosophila melanogaster)
BTRC:CUL1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
GLI3 is processed to GLI3R by the proteasome (Drosophila melanogaster)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Drosophila melanogaster)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
Iron uptake and transport (Drosophila melanogaster)
CANDI binds CUL1 (Drosophila melanogaster)
CANDI:CUL1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:FBXL5 [cytosol] (Drosophila melanogaster)
Cul1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24311 Cul1
Gene Names
Cul1, cul-1, lin19, CG1877
Chain
chain:1-774
Reference Genes
BioGPS Gene:35742 Cul1
KEGG Gene (Drosophila melanogaster):Dmel_CG1877 Cul1
Monarch:35742 Cul1
NCBI Gene:35742 Cul1
UCSC:Q24311 Cul1
Reference Transcript
RefSeq:NM_165571.2 Cul1
RefSeq:NM_165570.3 Cul1
RefSeq:NM_078931.4 Cul1
RefSeq:NM_165569.2 Cul1
Other Identifiers
153960_at
1624407_s_at
35742
GO:0002376
GO:0002785
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006511
GO:0007059
GO:0012501
GO:0014067
GO:0016567
GO:0019005
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030674
GO:0031146
GO:0031398
GO:0031461
GO:0031625
GO:0032436
GO:0035331
GO:0036211
GO:0043066
GO:0043226
GO:0045879
GO:0046627
GO:0048856
GO:0051898
GO:0060090
GO:0061060
GO:0070979
GO:0090090
GO:0098542
GO:0140013
GO:1904801
GO:1905088
Participates
as an input of
Formation of the SCF-FBXL7 complex (Drosophila melanogaster)
CANDI binds CUL1 (Drosophila melanogaster)
as a component of
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Drosophila melanogaster)
CANDI:CUL1 [cytosol] (Drosophila melanogaster)
SKP1:CUL1:FBXL5 [cytosol] (Drosophila melanogaster)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
BTRC:CUL1:SKP1 [cytosol] (Drosophila melanogaster)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Other forms of this molecule
LIN19 [cytosol]
Cul1 [cytosol]
Cul1 [nucleoplasm]
Inferred From
CUL1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_724621.1
,
NP_724623.1
,
NP_724622.1
,
NP_523655.1
Flybase
FBgn0015509
PRO
Q24311
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O77430 skpA
3
SKPA [cytosol]
(R-DME-205785)
SkpA [nucleoplasm]
(R-DME-187538)
SkpA [cytosol]
(R-DME-174150)
0.534
3
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