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phospho-p-S176,S180-CHUK [cytosol]
Stable Identifier
R-DME-177667
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q9VEZ5
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
TNFR2 non-canonical NF-kB pathway (Drosophila melanogaster)
NIK-->noncanonical NF-kB signaling (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Drosophila melanogaster)
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Drosophila melanogaster)
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
Dectin-1 mediated noncanonical NF-kB signaling (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Drosophila melanogaster)
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Drosophila melanogaster)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Drosophila melanogaster)
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
Cytosolic sensors of pathogen-associated DNA (Drosophila melanogaster)
ZBP1(DAI) mediated induction of type I IFNs (Drosophila melanogaster)
RIP-mediated NFkB activation via ZBP1 (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Drosophila melanogaster)
TRAF6 mediated NF-kB activation (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
TNF signaling (Drosophila melanogaster)
Regulation of TNFR1 signaling (Drosophila melanogaster)
CHUK, IKBKB phosphorylate CYLD at S418 (Drosophila melanogaster)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Drosophila melanogaster)
phospho-p-S176,S180-CHUK [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VEZ5 IKKbeta
Gene Names
IKKbeta, DIK, ird5, CG4201
Chain
chain:1-751
Reference Genes
BioGPS Gene:44432 IKKbeta
KEGG:dme:Dmel_CG4201 IKKbeta
Monarch:44432 IKKbeta
NCBI Gene:44432 IKKbeta
UCSC:Q9VEZ5 IKKbeta
Reference Transcript
RefSeq:NM_080012.4 IKKbeta
Other Identifiers
142654_at
1625974_at
44432
GO:0002230
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006355
GO:0006468
GO:0006963
GO:0008384
GO:0008385
GO:0016740
GO:0019731
GO:0030163
GO:0033209
GO:0042802
GO:0043123
GO:0045087
GO:0045088
GO:0045944
GO:0051607
GO:0061057
GO:0071456
GO:0098542
GO:0140096
GO:0140896
Participates
as a component of
p-S176,S180-IKKA dimer [cytosol] (Drosophila melanogaster)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Drosophila melanogaster)
Other forms of this molecule
IRD5 [cytosol]
Phospho IRD5 [cytosol]
phospho-p-Y187,Y198-CHUK [cytosol]
phospho-p-T23-CHUK [cytosol]
phospho-p-S177,S181-IKBKB [cytosol]
CHUK [cytosol]
IKBKB [cytosol]
Inferred From
p-S176,S180-CHUK [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 176 (in Homo sapiens)
Coordinate
176
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 180 (in Homo sapiens)
Coordinate
180
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_524751.3
ENSEMBL
FBtr0304804
,
FBpp0293344
FlyBase
FBgn0024222
PRO
Q9VEZ5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GYV5 key
10
KEY [cytosol]
(R-DME-206178)
OPTN [recycling endosome membrane]
(R-DME-8854141)
IKBKG [nucleoplasm]
(R-DME-4755413)
OPTN [Golgi membrane]
(R-DME-2161111)
phospho-p-S177-OPTN [nucleoplasm]
(R-DME-2562595)
phospho-p-S177-OPTN [cytosol]
(R-DME-2562525)
K63polyUb-IKBKG [cytosol]
(R-DME-202530)
IKBKG [cytosol]
(R-DME-168108)
OPTN [cytosol]
(R-DME-9687907)
phospho-p-S177,S473,S513-OPTN [cytosol]
(R-DME-9687840)
0.632
4
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-p-Y187,Y198-CHUK [cytosol]
(R-DME-9861501)
phospho-p-T23-CHUK [cytosol]
(R-DME-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-DME-177667)
phospho-p-S177,S181-IKBKB [cytosol]
(R-DME-202506)
CHUK [cytosol]
(R-DME-168104)
IKBKB [cytosol]
(R-DME-168114)
0.623
2
UniProt:Q03017 cact
6
CACT [cytosol]
(R-DME-205871)
Phospho CACT [cytosol]
(R-DME-205886)
cact [nucleoplasm]
(R-DME-4656929)
phospho-cact [cytosol]
(R-DME-1168581)
phospho-cact [cytosol]
(R-DME-177677)
cact [cytosol]
(R-DME-168151)
0.544
2
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