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EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
Stable Identifier
R-DME-180286
Type
Complex
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol]
(Drosophila melanogaster)
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
as an output of
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
Inferred From
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
(Homo sapiens)
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