Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-dos [cytosol]
Stable Identifier
R-DME-180344
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-5Y-GAB1, Q9VZZ9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
phospho-dos [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VZZ9
Gene Names
dos
Reference Genes
BioGPS Gene:38321 dos
CTD Gene:38321 dos
ENSEMBL:FBgn0016794
FlyBase:FBgn0016794
KEGG:dme:Dmel_CG1044 dos
Monarch:38321 dos
NCBI Gene:38321 dos
UCSC:Q9VZZ9 dos
Reference Transcript
RefSeq:NM_079166.3 dos
RefSeq:NM_167956.2 dos
Other Identifiers
141511_at
144032_at
1628775_s_at
1640395_a_at
38321
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0007465
GO:0008293
GO:0008595
GO:0016020
GO:0035591
GO:0042169
GO:0042461
GO:0045500
GO:0046578
GO:0048856
GO:0060090
Participates
as a component of
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
phospho-dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
dos [cytosol]
Inferred From
p-5Y-GAB1,p-5Y-GAB2 [cytosol]
(Homo sapiens)
p-5Y-GAB1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 627 (in Homo sapiens)
Coordinate
627
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 659 (in Homo sapiens)
Coordinate
659
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 447 (in Homo sapiens)
Coordinate
447
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 472 (in Homo sapiens)
Coordinate
472
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 589 (in Homo sapiens)
Coordinate
589
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_728757.1
,
NP_523890.2
ENSEMBL
FBgn0016794
,
FBpp0072803
,
FBtr0072926
FlyBase
FBgn0016794
PRO
Q9VZZ9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08012
3
drk [cytosol]
(R-DME-202367)
drk [plasma membrane]
(R-DME-202993)
drk [cytosol]
(R-DME-74686)
0.667
6
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text