Reactome | EloC [cytosol]

EloC [cytosol]

Stable Identifier

R-DME-180535

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

ELOC, Q7JWD6

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to hypoxia (Drosophila melanogaster)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
      - Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
        
        VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
        
        VBC complex [cytosol] (Drosophila melanogaster)
        
        EloC [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7JWD6

Gene Names

EloC

Reference Genes

BioGPS Gene:37237 EloC

ENSEMBL:FBgn0266711

FlyBase:FBgn0266711

KEGG Gene (Drosophila melanogaster):Dmel_CG9291 EloC

Monarch:37237 EloC

NCBI Gene:37237 EloC

UCSC:Q7JWD6 EloC

Reference Transcript

Other Identifiers

143979_at

1624742_a_at

37237

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006368

GO:0006511

GO:0007474

GO:0016032

GO:0023052

GO:0030163

GO:0030674

GO:0031462

GO:0043226

GO:0046426

GO:0048856

GO:0060090

GO:0070449

Participates

as a component of

Other forms of this molecule

EloC [nucleoplasm]

Inferred From

ELOC [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_725894.1, NP_523794.1

Flybase

FBgn0266711

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O44226	2	EloB [nucleoplasm] (R-DME-112423) EloB [cytosol] (R-DME-180551)	0.667	4
UniProt:Q7JVF1	1	Socs44A [cytosol] (R-DME-1469969)	0.573	2
UniProt:Q9VYM8 Q9VYM8			0.547	2
UniProt:Q9V9R2	3	Cul2 [cytosol] (R-DME-8952511) Cul2 [nucleoplasm] (R-DME-1234126) Cul2 [cytosol] (R-DME-416982)	0.547	2

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