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Hrd3 [endoplasmic reticulum membrane]
Stable Identifier
R-DME-1911545
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
endoplasmic reticulum membrane
Synonyms
SEL1L, Q9V415
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
Hrd3 [endoplasmic reticulum membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V415
Gene Names
Hrd3
Reference Genes
BioGPS Gene:42806 Hrd3
ENSEMBL:FBgn0028475
Flybase:FBgn0028475
KEGG Gene (Drosophila melanogaster):Dmel_CG10221 Hrd3
Monarch:42806 Hrd3
NCBI Gene:42806 Hrd3
UCSC:Q9V415 Hrd3
Reference Transcript
RefSeq:NM_001275953.1 Hrd3
RefSeq:NM_142922.3 Hrd3
Other Identifiers
144215_at
1632236_at
42806
GO:0005515
GO:0005783
GO:0005789
GO:0016020
GO:0030163
GO:0036503
GO:0043226
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Drosophila melanogaster)
ERAD complex [endoplasmic reticulum membrane] (Drosophila melanogaster)
Inferred From
SEL1L [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
RefSeq
NP_651179.1
,
NP_001262882.1
Flybase
FBgn0028475
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