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sif [cytosol]
Stable Identifier
R-DME-195013
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
TIAM1, P91621
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPH-ephrin mediated repulsion of cells (Drosophila melanogaster)
EPHA binds TIAM1 (Drosophila melanogaster)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
EPHB phosphorylates TIAM1 (Drosophila melanogaster)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
Cell death signalling via NRAGE, NRIF and NADE (Drosophila melanogaster)
NRAGE signals death through JNK (Drosophila melanogaster)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)
GEFs [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (12/13) signalling events (Drosophila melanogaster)
GEFs activate RhoA,B,C (Drosophila melanogaster)
GEFs [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
CDC42 GTPase cycle (Drosophila melanogaster)
CDC42 GEFs activate CDC42 (Drosophila melanogaster)
CDC42 GEFs [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 GEFs activate RAC2 (Drosophila melanogaster)
RAC2 GEFs [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 GEFs activate RAC3 (Drosophila melanogaster)
RAC3 GEFs [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
RHOA GTPase cycle (Drosophila melanogaster)
RHOA GEFs activate RHOA (Drosophila melanogaster)
RHOA GEFs [cytosol] (Drosophila melanogaster)
sif [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P91621
Gene Names
sif
Reference Genes
BioGPS Gene:43892 sif
CTD Gene:43892 sif
ENSEMBL:FBgn0085447
Flybase:FBgn0085447
KEGG Gene (Drosophila melanogaster):Dmel_CG34418 sif
Monarch:43892 sif
NCBI Gene:43892 sif
Reference Transcript
RefSeq:NM_001104049.4 sif
RefSeq:NM_168126.4 sif
Other Identifiers
1637828_a_at
43892
GO:0001654
GO:0005085
GO:0005515
GO:0007010
GO:0007165
GO:0007264
GO:0007601
GO:0016020
GO:0016043
GO:0023052
GO:0030036
GO:0030154
GO:0035556
GO:0043087
GO:0045202
GO:0048856
GO:0050770
GO:0050772
GO:0050803
GO:0050877
GO:0051491
GO:0090630
GO:0098772
Participates
as a candidate of
RHOA GEFs [cytosol] (Drosophila melanogaster)
CDC42 GEFs [cytosol] (Drosophila melanogaster)
as a member of
RAC2 GEFs [cytosol] (Drosophila melanogaster)
RAC3 GEFs [cytosol] (Drosophila melanogaster)
GEFs [cytosol] (Drosophila melanogaster)
as an input of
EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)
EPHA binds TIAM1 (Drosophila melanogaster)
as a component of
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Drosophila melanogaster)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
phospho-sif [cytosol]
sif [cytosol]
Inferred From
TIAM1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_729084.1
,
NP_001097519.2
Flybase
FBgn0085447
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