Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking

Stable Identifier
R-DME-1984022
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
cytosol, endoplasmic reticulum lumen
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking

In Drosophila, mutations that lead to the loss of function of endoplasmic reticulum membrane calcium ATPase Ca-P60A result in impaired Notch cleavage by furin (although furin is not directly affected) and Notch trafficking to the cell surface. This could be due to Notch misfolding in the endoplasmic reticulum at suboptimal concentrations of calcium.

Literature References
PubMed ID Title Journal Year
10545110 Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila

Fortini, ME, Periz, G

EMBO J 1999
Participants
Input
Output
This event is regulated
Positively by
Regulator
Ca-P60A [endoplasmic reticulum membrane] (Drosophila melanogaster)
Orthologous Events
Transport of NOTCH precursor to Golgi (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-11)
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