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Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking
Stable Identifier
R-DME-1984022
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
cytosol
,
endoplasmic reticulum lumen
ReviewStatus
5/5
General
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In Drosophila, mutations that lead to the loss of function of endoplasmic reticulum membrane calcium ATPase Ca-P60A result in impaired Notch cleavage by furin (although furin is not directly affected) and Notch trafficking to the cell surface. This could be due to Notch misfolding in the endoplasmic reticulum at suboptimal concentrations of calcium.
Literature References
PubMed ID
Title
Journal
Year
10545110
Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
Fortini, ME
,
Periz, G
EMBO J
1999
Participants
Input
Glc,Fuc-N [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Output
Glc,Fuc-N [Golgi lumen]
(Drosophila melanogaster)
This event is regulated
Positively by
Regulator
Ca-P60A [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Orthologous Events
Transport of NOTCH precursor to Golgi (Homo sapiens)
Authored
Orlic-Milacic, M (2011-11-14)
Egan, SE (2011-11-14)
Reviewed
Haw, R (2012-02-06)
Created
Orlic-Milacic, M (2011-11-11)
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