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MAPK1 [nucleoplasm]
Stable Identifier
R-DME-199960
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
P40417
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
ERK/MAPK targets (Drosophila melanogaster)
ERKs are inactivated (Drosophila melanogaster)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)
MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Drosophila melanogaster)
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
MAPK1 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P40417
Reference Genes
BioGPS Gene:3354888
CTD Gene:3354888
ENSEMBL:FBgn0003256
FlyBase:FBgn0003256
KEGG Gene (Drosophila melanogaster):Dmel_CG12559
Monarch:3354888
NCBI Gene:3354888
Reference Transcript
RefSeq:NM_001015121.3
RefSeq:NM_001015123.3
RefSeq:NM_001015122.3
RefSeq:NM_001110879.2
RefSeq:NM_001300706.2
RefSeq:NM_001110878.4
Other Identifiers
1629549_s_at
3354888
GO:0000165
GO:0000166
GO:0000278
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0007049
GO:0007154
GO:0007166
GO:0007173
GO:0007362
GO:0007430
GO:0007465
GO:0007474
GO:0007476
GO:0007479
GO:0007552
GO:0008284
GO:0008286
GO:0008293
GO:0008340
GO:0008543
GO:0009267
GO:0009605
GO:0016242
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0031594
GO:0033554
GO:0034614
GO:0035169
GO:0035170
GO:0035202
GO:0035556
GO:0036211
GO:0042060
GO:0043226
GO:0045500
GO:0045793
GO:0046534
GO:0046843
GO:0048010
GO:0048149
GO:0048856
GO:0050804
GO:0051091
GO:0051607
GO:0060446
GO:0070371
GO:0071243
GO:0071276
GO:0090303
GO:0098542
GO:0106310
GO:0140096
GO:0140297
GO:2000826
GO:2001023
Participates
as a member of
MAPK monomers and dimers [nucleoplasm] (Drosophila melanogaster)
as a component of
MAPK1 dimer [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T185,Y187-MAPK1 [cytosol]
MAPK1 [cytosol]
MAPK3 [cytosol]
MAPK3 [nucleoplasm]
phospho-p-T185-MAPK1 [cytosol]
phospho-p-T202-MAPK3 [cytosol]
phospho-p-Y204-MAPK3-3 [cytosol]
MAPK1 [azurophil granule lumen]
MAPK1 [extracellular region]
MAPK1 [ficolin-1-rich granule lumen]
Inferred From
MAPK1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001015122.1
,
NP_001015123.1
,
NP_001015121.3
,
NP_001104349.1
,
NP_001104348.2
,
NP_001287635.1
Flybase
FBgn0003256
IntEnz
2.7.11.24
PRO
P40417
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9U1H0 CIC
0.593
3
UniProt:Q24106 HID
0.59
3
UniProt:Q9V393 krz
10
krz [cytoplasmic vesicle membrane]
(R-DME-351187-3)
krz [Golgi membrane]
(R-DME-350831-3)
krz [lysosomal membrane]
(R-DME-432701-3)
krz [endocytic vesicle membrane]
(R-DME-9910881)
krz [endocytic vesicle membrane]
(R-DME-9910882-3)
krz [cytosol]
(R-DME-6783000)
krz [cytosol]
(R-DME-6783186-3)
Krz [cytosol]
(R-DME-2071841)
krz [cytosol]
(R-DME-416464)
krz [cytosol]
(R-DME-264470-3)
0.544
12
UniProt:Q24324 Dsor1
9
DSOR1 [cytosol]
(R-DME-205968)
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
(R-DME-5674490)
phospho-p-S,T-MAP2K2 [cytosol]
(R-DME-109848)
phospho-p-T286,T292-MAP2K1 [cytosol]
(R-DME-112374)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-DME-112339)
MAP2K1 [cytosol]
(R-DME-59502)
MAP2K2 [cytosol]
(R-DME-59504)
phospho-p-S222,S226-MAP2K2 [cytosol]
(R-DME-169292)
phospho-p-S218,S222-MAP2K1 [cytosol]
(R-DME-109837)
0.534
2
UniProt:Q24496 Q24496
0.524
2
UniProt:P21461
2
SIAH2 [cytosol]
(R-DME-374566)
SIAH1 [cytosol]
(R-DME-374563)
0.488
2
UniProt:Q9W2K3 Q9W2K3
0.488
2
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