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PARP1 [nucleoplasm]
Stable Identifier
R-DME-201568
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
P35875
Locations in the PathwayBrowser
Expand all
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
POLB-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
DNA Damage Recognition in GG-NER (Drosophila melanogaster)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
SUMOylation (Drosophila melanogaster)
SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
SUMOylation of DNA damage response and repair proteins (Drosophila melanogaster)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Drosophila melanogaster)
PARP1 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P35875
Reference Genes
BioGPS Gene:3355109
ENSEMBL:FBgn0010247
Flybase:FBgn0010247
KEGG Gene (Drosophila melanogaster):Dmel_CG40411
Monarch:3355109
NCBI Gene:3355109
Reference Transcript
RefSeq:NM_001110982.3
Other Identifiers
3355109
GO:0000791
GO:0002376
GO:0003677
GO:0003824
GO:0003950
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005700
GO:0005703
GO:0005730
GO:0006281
GO:0006302
GO:0006325
GO:0006963
GO:0006974
GO:0007000
GO:0007163
GO:0008069
GO:0008270
GO:0015030
GO:0016740
GO:0016757
GO:0016779
GO:0022414
GO:0023052
GO:0030154
GO:0030576
GO:0035079
GO:0035080
GO:0035363
GO:0036211
GO:0042393
GO:0043226
GO:0043484
GO:0045087
GO:0046872
GO:0048856
GO:0051287
GO:0051457
GO:0061059
GO:0070212
GO:0090734
GO:0098542
GO:0140096
GO:0140805
GO:1900182
GO:1902275
GO:1990404
Participates
as an input of
PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
as a component of
PARP1,PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Drosophila melanogaster)
as an output of
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)
Other forms of this molecule
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
PAR-PARP1 [nucleoplasm]
Inferred From
PARP1,PARP2 [nucleoplasm]
(Homo sapiens)
PARP1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001104452.1
Flybase
FBgn0010247
IntEnz
2.4.2.30
PRO
P35875
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24368
1
SMARCA5 [nucleoplasm]
(R-DME-417140)
0.632
4
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