Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
pan [nucleoplasm]
Stable Identifier
R-DME-201923
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
TCF7L2, Q8IMA8
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
RUNX3 regulates WNT signaling (Drosophila melanogaster)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Repression of WNT target genes (Drosophila melanogaster)
TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)
TCF7L2/TCF7L1:CTBPs [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Drosophila melanogaster)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Deactivation of the beta-catenin transactivating complex (Drosophila melanogaster)
TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
Formation of the beta-catenin:TCF transactivating complex (Drosophila melanogaster)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
Beta-catenin recruits CBP/p300 (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
SET1 complex trimethylates H3K4 at the MYC gene (Drosophila melanogaster)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Drosophila melanogaster)
pan [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q8IMA8
Gene Names
pan
Reference Genes
BioGPS Gene:43769 pan
CTD Gene:43769 pan
ENSEMBL:FBgn0085432
Flybase:FBgn0085432
Monarch:43769 pan
NCBI Gene:43769 pan
Reference Transcript
RefSeq:NM_166724.4 pan
Other Identifiers
142459_at
1625636_s_at
1629467_at
43769
GO:0000978
GO:0000981
GO:0001222
GO:0001228
GO:0003677
GO:0005634
GO:0005667
GO:0006351
GO:0006355
GO:0006357
GO:0007367
GO:0007435
GO:0007476
GO:0007500
GO:0007507
GO:0009880
GO:0010628
GO:0016055
GO:0019900
GO:0023052
GO:0030154
GO:0035277
GO:0035293
GO:0043226
GO:0045892
GO:0045893
GO:0045944
GO:0048546
GO:0048856
GO:0060070
GO:0072091
GO:0090254
GO:0140110
GO:1990907
Participates
as a component of
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Drosophila melanogaster)
TCF7L2/TCF7L1:CTBPs [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Drosophila melanogaster)
TCF/LEF:CTNNB1 [nucleoplasm] (Drosophila melanogaster)
as an input of
TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)
Other forms of this molecule
phospho-pan [nucleoplasm]
phospho-pan [nucleoplasm]
pan [nucleoplasm]
pan [nucleoplasm]
pan [nucleoplasm]
Inferred From
TCF7L2/TCF7L1 [nucleoplasm]
(Homo sapiens)
TCF/LEF [nucleoplasm]
(Homo sapiens)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm]
(Homo sapiens)
TCF7L2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_726528.2
Flybase
FBgn0085432
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text